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Description
TCI D4164 Difluoroacetic Anhydride is a fluorinated acid anhydride that acts as a strong acylating reagent for introducing the difluoroacetyl group into target molecules. As a fluorinated building block, this compound provides a direct route to amides, esters, and ketones carrying the difluoromethyl motif, without the need to go through a separate fluorination step. In the laboratory, a reagent of this kind occupies an important position because it can complete the transformation in a single clean stage, with difluoroacetic acid as the by-product, which is relatively easy to separate during purification.
Its principal characteristic is high reactivity toward nucleophiles such as amines, alcohols, and activated aromatic compounds, resulting from a carbonyl group that is strongly activated by the fluorine atoms at the alpha position. This reactivity allows acylation to proceed rapidly under mild conditions, but it also means the compound is highly sensitive to water and atmospheric moisture, and therefore demands anhydrous working technique. The difluoromethyl group it transfers is much sought after in molecular design because it can modify the acidity, lipophilicity, and metabolic stability of the derived compounds in a directed and predictable manner.
In Indonesian laboratories, this reagent is generally used in university and institutional research groups as well as in industrial research units working on fine chemical and pharmaceutical intermediate synthesis. It is normally handled in modest quantities on a bench scale, within a schedule of work that has been planned in advance, since the reagent must be taken from storage, used, and returned under conditions that keep moisture away. Sound planning of this kind keeps the material usable across a series of experiments.
Laboratory Applications
- Amide synthesis: the anhydride reacts readily with primary and secondary amines to give difluoroacetamides in one step, avoiding a separate activation or coupling stage.
- Ester preparation: alcohols are acylated rapidly under mild conditions, making the reagent suitable for installing the difluoroacetyl group on hydroxyl-bearing substrates without harsh reaction settings.
- Friedel-Crafts type acylation of activated aromatic compounds, where the strongly activated carbonyl allows the difluoroacetyl group to be introduced onto electron-rich aromatic rings.
- Fluorinated building block chemistry: the compound supplies the difluoromethyl motif directly, so a synthetic route can bypass a dedicated fluorination step and the handling it would require.
- Medicinal chemistry and molecular design studies, where the difluoromethyl group is used deliberately to adjust acidity, lipophilicity, and metabolic stability of the target derivatives.
Specifications
- Brand: TCI
- CAS number: 401-67-2
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Chemical class: fluorinated acid anhydride, acylating reagent
- Pack sizes: available in the pack sizes offered by TCI for this catalogue item
- Storage: keep in a tightly closed container under dry conditions, protected from moisture
Handling and Storage
Because the anhydride is highly sensitive to water and atmospheric humidity, store it in a tightly sealed original container, protected from moisture and kept away from sources of ignition and from incompatible materials such as amines, alcohols, and bases. Handle the reagent inside a functioning fume hood using anhydrous technique: dry glassware, dry solvents, and an inert atmosphere where the procedure allows. Wear chemical-resistant gloves, safety goggles, and a laboratory coat, since the compound and its difluoroacetic acid by-product are corrosive to skin and eyes. Transfer only the quantity needed, reseal the container promptly to limit exposure to humid air, and return it to designated storage. Follow the manufacturer's safety data sheet and your institution's chemical waste procedures for disposal of residues and quench solutions.
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