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Description
TCI D4189 Dorzolamide Hydrochloride, CAS 130693-82-2, is a biochemical reagent belonging to the enzyme inhibitor group. The compound is the hydrochloride salt of a cyclic sulfonamide derivative built on a thienothiopyran system, a scaffold widely recognised as an inhibitor of the enzyme carbonic anhydrase. In the laboratory, this material is used as a reference compound in enzyme activity assays, in studies of inhibition mechanisms, and in pharmacological research that examines the role of carbonic anhydrase in the regulation of ionic balance and tissue pH.
The principal property that makes this compound a frequent choice is the presence of a primary sulfonamide group, which interacts strongly with the zinc ion at the catalytic site of carbonic anhydrase, so that inhibition proceeds in a specific and consistent manner. The hydrochloride form improves solubility in aqueous media compared with the free base, making the preparation of stock solutions more practical and reducing the need for organic solvents that can interfere with enzymatic systems. The salt form also makes the material easier to handle and to prepare in aqueous solution systems for assay purposes. As a TCI product, purity and lot-to-lot consistency support reproducible results.
In Indonesian laboratories, this reagent is typically used in biochemistry and pharmacology research settings where carbonic anhydrase activity is measured or modulated. It serves as a comparator in inhibition studies, as a positive control alongside candidate inhibitors, and as a working standard in method development. Its ready dissolution in aqueous buffers suits routine assay workflows in academic, institutional, and industrial research laboratories that require dependable enzyme inhibitor reference material.
Laboratory Applications
- Enzyme activity assays — serves as a reference inhibitor whose consistent interaction with carbonic anhydrase provides a dependable benchmark against which measured enzyme activity can be compared.
- Inhibition mechanism studies — the well-defined primary sulfonamide interaction with the catalytic zinc ion makes it suitable for investigating how sulfonamide inhibitors bind and suppress carbonic anhydrase.
- Pharmacological research on ion balance — used to explore the role of carbonic anhydrase in the regulation of ionic balance within tissues, where specific and consistent inhibition is required.
- Tissue pH regulation studies — the compound allows researchers to probe carbonic anhydrase involvement in tissue pH control, since its inhibition is both specific and reproducible across experiments.
- Aqueous assay system preparation — the hydrochloride salt dissolves readily in aqueous media, so stock solutions can be prepared without organic solvents that would otherwise disturb enzymatic systems.
Specifications
- Brand: TCI
- CAS number: 130693-82-2
- Catalogue number: D4189
- Category: Life Science > Biochemicals and Reagents > Enzymes, Enzyme Inhibitors, Enzyme Substrates
- Product type: hydrochloride salt of a thienothiopyran cyclic sulfonamide derivative; enzyme inhibitor reagent
- Pack sizes: available in standard laboratory reagent pack sizes; please refer to the current catalogue listing
- Storage: store according to the conditions stated on the product label and accompanying documentation
Handling and Storage
Store the reagent in its original tightly closed container, kept in a cool, dry, and well-ventilated place away from direct sunlight, moisture, and incompatible materials, following the storage conditions stated on the product label and safety data sheet. Use clean, dry glassware or chemically compatible containers when weighing and preparing stock solutions, and close the container promptly after use to limit moisture uptake. Handle the material in a fume hood or a well-ventilated working area, wearing a laboratory coat, safety glasses, and suitable gloves. Prepared aqueous solutions should be clearly labelled with the compound name, concentration, and preparation date, and handled in accordance with the laboratory's standard operating procedures for biochemical reagents. Consult the safety data sheet before first use and for waste disposal guidance.
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