TCI D4246 Decyldimethyl(3-sulfopropyl)ammonium Hydroxide Inner Salt (CAS 15163-36-7) is a zwitterionic surfactant of the sulfobetaine class carrying a ten-carbon alkyl chain, supplied by TCI in a grade intended for biochemical research. The molecule bears a positive charge on its quaternary ammonium group and a negative charge on its sulfonate group within a single molecular body, so it remains electrically neutral overall across a wide pH range. This property is what makes it a dependable reagent for solubilizing membrane proteins, preparing electrophoresis samples, and controlling particle surfaces in nanomaterial research.
The characteristic that leads researchers to select this sulfobetaine is its combination of good solubilizing power with relatively mild, non-denaturing behavior compared with ionic surfactants such as SDS. Because its net charge is zero, the surfactant does not interfere with charge-based separations, making it suitable for isoelectric focusing electrophoresis and two-dimensional proteomic analysis. The decyl chain provides a balance between hydrophobicity sufficient to penetrate lipid environments and ease of removal once a procedure is complete. In colloidal quantum dot research, the ammonium and sulfonate groups play a role in interacting with and stabilizing particle surfaces.
In Indonesian laboratories, this reagent is typically used in university biochemistry and molecular biology groups, government research institutes, and materials science laboratories working on nanomaterials and electronic materials. It is applied in protein extraction and sample preparation workflows, in electrophoresis-based analytical methods, and in colloidal quantum dot studies within materials science programmes. It is generally handled as a research-scale consumable, drawn from a shared reagent inventory and weighed out per experiment rather than used in bulk process work.
- Membrane protein solubilization: the zwitterionic sulfobetaine structure extracts proteins from lipid environments while its mild, relatively non-denaturing character helps preserve protein integrity better than strongly ionic surfactants.
- Isoelectric focusing electrophoresis: because the molecule carries zero net charge across a wide pH range, it solubilizes sample components without distorting the charge-based separation on which the technique depends.
- Two-dimensional proteomic analysis: the surfactant keeps complex protein mixtures in solution during sample preparation without introducing charge artefacts that would compromise the first-dimension separation.
- Colloidal quantum dot surface control: the ammonium and sulfonate groups interact with and stabilize particle surfaces, supporting surface chemistry work in electronic and nanomaterial research programmes.
- General electrophoresis sample preparation: the decyl chain gives enough hydrophobicity to disperse difficult samples while remaining straightforward to wash out once the preparation step is finished.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 15163-36-7 |
| Molecular formula | — |
| Purity | — |
| Category | Materials Science > Electronic Materials > Colloidal Quantum Dot (QD) Research Reagents |
| Pack sizes | available in standard TCI research-scale pack sizes; refer to the product label and manufacturer documentation for the applicable pack size and storage temperature. |
| Physical form | — |
| Storage | — |
- Chemical name: Decyldimethyl(3-sulfopropyl)ammonium Hydroxide Inner Salt
- Grade: for Biochemical Research
Store the container tightly closed in a cool, dry place away from direct sunlight and sources of moisture, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original TCI container or in a clean, well-sealed, chemically compatible vessel that is clearly labelled with the product name and CAS number. Weigh and transfer the solid in a well-ventilated area or fume hood, using a clean spatula to avoid contaminating the stock. Wear a laboratory coat, safety glasses, and suitable gloves during handling, avoid generating dust, and wash hands after use. Dispose of surplus material and contaminated consumables through your institution's chemical waste procedures.
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