TCI
Dimethyl(n-octyl)(3-sulfopropyl)ammonium Hydroxide Inner Salt [for Biochemical Research] TCI D4247
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Description
TCI D4247 Dimethyl(n-octyl)(3-sulfopropyl)ammonium Hydroxide Inner Salt (CAS 15178-76-4) is a zwitterionic surfactant of the sulfobetaine class, built around an eight-carbon alkyl chain and supplied by TCI at a grade intended for biochemical research. Like other members of the sulfobetaine family, the molecule carries a positively charged quaternary ammonium group and a negatively charged sulfonate group at the same time, so it holds a net charge of zero across a broad pH range. This reagent is widely used for solubilizing proteins, preparing samples for analysis, controlling interfacial properties, and stabilizing colloidal systems in nanocrystal-based electronic materials research.
The property that sets this octyl variant apart is its shorter hydrophobic chain compared with the decyl derivative, which changes both micelle-forming behavior and the strength of its interaction with lipid environments. A shorter chain generally produces micelles that are easier to disassemble and easier to remove by dialysis — a clear advantage when researchers need to strip the surfactant away once the solubilization step is complete. Its zwitterionic character keeps it gentle toward protein structure while avoiding interference with charge-based separation methods, making it a practical choice where harsher ionic detergents would be unsuitable.
In Indonesian laboratories, this reagent fits naturally into university and institutional research programs working on membrane protein preparation, sample workup for analytical measurement, and colloidal quantum dot (QD) work within materials science groups. It is typically ordered as part of a broader biochemical reagent set for method development and repeated small-scale experiments, where reliable zwitterionic behavior over a wide pH window matters more than large working volumes. Its position in the electronic materials category also suits groups combining biochemical technique with nanomaterial surface chemistry.
Laboratory Applications
- Membrane protein solubilization — the zwitterionic head group extracts and keeps proteins in solution without the denaturing pressure that strongly ionic detergents place on native structure.
- Sample preparation for analysis — the reagent conditions samples ahead of analytical measurement, while its net-zero charge avoids interfering with charge-based separation and downstream detection steps.
- Colloidal quantum dot research — it stabilizes colloidal systems in nanocrystal-based electronic materials work, helping maintain dispersion quality during handling of quantum dot preparations.
- Interfacial property control — the paired ammonium and sulfonate groups allow researchers to tune surface and interfacial behavior across a broad pH range without adding net charge.
- Post-solubilization surfactant removal — the shorter octyl chain forms micelles that disassemble more readily, so the detergent can be cleared by dialysis after solubilization is finished.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 15178-76-4
- Category: Materials Science > Electronic Materials > Colloidal Quantum Dot (QD) Research Reagents
- Grade: for biochemical research
- Pack sizes: available in standard TCI research-scale catalogue packs; please confirm the size required when ordering
- Storage: store as indicated on the manufacturer's label and accompanying documentation
Handling and Storage
Store the container tightly closed in a cool, dry place, away from moisture, direct sunlight, and sources of heat, following the conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original tightly sealed container, or transfer it to a clean, dry, chemically compatible vessel that is clearly labelled with the product name and CAS number. Because sulfobetaine surfactants readily pick up ambient moisture, minimize the time the container stays open and reseal it promptly after weighing. Handle the powder in a well-ventilated area or fume hood, wear a laboratory coat, safety glasses, and suitable gloves, and avoid generating dust. Consult the current safety data sheet before use and dispose of residues and contaminated materials in line with institutional chemical waste procedures.
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