Dansylglycine [for Albumin binding assay] TCI D5406

Chemical Identity

Other names: N-[5-(Dimethylamino)naphthalene-1-sulfonyl]glycine · Dns-Gly-OH
CAS No.: 1091-85-6
PubChem: CID 70666·SID 354335222
Formula: C14H16N2O4S
Molecular weight: 308.35 g/mol
Purity: >98.0%(T)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]acetic acid
SMILES: CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NCC(=O)O
InChIKey: QHFXORCWAQTTGH-UHFFFAOYSA-N
MDL: MDL00037734

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Dansylglycine is a chemical compound widely used in scientific research, particularly in pharmacology and biochemistry. It plays a crucial role in laboratory settings by serving as an albumin-binding agent, enabling the analysis of albumin levels in plasma or other biological fluids. This compound is essential for studies related to drug development and understanding how drugs interact within the human body. Its application extends to various research fields where precise measurement of albumin is required.

The unique properties of Dansylglycine make it a preferred choice for analytical purposes. It exhibits strong fluorescent characteristics, which significantly enhance detection and measurement through spectroscopy techniques. This fluorescence allows for highly sensitive and accurate analysis, making it ideal for modern analytical methods. Additionally, its ability to bind specifically to albumin ensures reliable and reproducible results in laboratory experiments.

In Indonesian laboratories, Dansylglycine is extensively used in scientific research across universities, research centers, and pharmaceutical companies. It is particularly relevant in drug interaction studies, new drug development, and biochemical analyses requiring high precision. Its role in supporting scientific innovation and research is vital, especially in the context of advancing pharmaceutical and biochemical studies in Indonesia.

Advantages (TCI brochure)

Selectively interacts with drug binding site II on HSA
Activity markedly lower with FA+ HSA, so FA- HSA is recommended

TCI brochures (PDF)

Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA 2025-04-01 · p. 1
Reagents for Biological Research 2025-03-11 · p. 26

Related TCI products

Albumin Binding Assay: This item is ideal for measuring albumin levels in biological samples due to its specific binding properties.
Drug Interaction Studies: Its fluorescent properties allow for accurate detection of drug-albumin interactions in pharmacological research.
Biochemical Analysis: The compound supports precise and sensitive measurements in biochemical experiments requiring high accuracy.
Pharmaceutical Development: It is essential for assessing drug binding behavior during the development of new therapeutic agents.
Research and Development: Its reliability and sensitivity make it a key reagent in various R&D projects within academic and industrial laboratories.

From the TCI brochure

Albumin binding assay
Confirming drug binding to site II on HSA
Drug discovery, R&D and metabolic toxicity assay

Brand	TCI
CAS number	1091-85-6
Molecular formula	—
Purity	—
Category	Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Albumin Binding Agents
Pack sizes	As per supplier specifications
Physical form	Solid (as per standard product description)
Storage	Store in a cool, dry place away from light

Data from the TCI brochure

Konsentrasi probe pada uji inhibisi	80 µM (HSA (FA-) 5 µM, 1% DMSO in 10mM phosphate buffer pH 7.2-7.5, 20-25°C, 30 menit)
Konsentrasi probe pada dose response	20 µM (dose response HSA (FA+/-), 20-25°C, 30 menit)
Excitation / emission	365 nm / 480 nm (plate reader)

Source: TCI brochure LL062 (2025-04-01)

Dansylglycine should be stored in a cool, dry place, away from direct light to maintain its stability and effectiveness. It is recommended to use airtight containers to prevent moisture absorption and contamination. Due to its fluorescent nature, it should be handled with care to avoid exposure to excessive light, which may degrade its properties. In laboratory settings, it is important to follow standard safety protocols, including the use of personal protective equipment. Proper labeling of containers is essential to ensure safe handling and prevent accidental use. The compound should be stored in a secure location to prevent unauthorized access and ensure compliance with laboratory safety standards.

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