BD140 [for Albumin binding assay] TCI D4898

Chemical Identity

Other names: BD140 · 4,4-Difluoro-1-methyl-3-(4-propoxystyryl)-4-bora-3a,4a-diaza-s-indacene
CAS No.: 1201643-08-4
PubChem: CID 72198885·SID 354333597
Formula: C21H21BF2N2O
Molecular weight: 366.22 g/mol
Purity: >98.0%(GC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2,2-difluoro-6-methyl-4-[(E)-2-(4-propoxyphenyl)ethenyl]-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaene
SMILES: [B-]1(N2C(=CC(=C2C=C3[N+]1=CC=C3)C)C=CC4=CC=C(C=C4)OCCC)(F)F
InChIKey: NDQRWYKJLFZGBK-RMKNXTFCSA-N

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TCI D4898 1201643-08-4 BD140 is a chemical compound specifically designed for use in albumin binding assays. This reagent plays a crucial role in laboratory research by enabling scientists to study how various molecules interact with albumin, a key protein in blood plasma. Albumin serves as a major carrier for many drugs, and understanding its binding behavior is essential for drug development and pharmacological research. This compound is widely utilized in laboratories to assess the stability and bioavailability of pharmaceutical compounds under physiological conditions.

The compound is known for its chemical stability and high purity, making it a preferred choice for scientific research. Its resistance to degradation ensures consistent results across multiple experiments, which is vital for reproducibility in scientific studies. Additionally, the material is highly transparent and free from interfering contaminants, which enhances the accuracy of analytical results. These properties make it suitable for use in a variety of research settings where precision and reliability are paramount.

In Indonesian laboratories, this reagent is commonly used in pharmaceutical, biochemical, and drug discovery research. Researchers in Indonesia rely on this compound to investigate molecular interactions that are critical for the development of new therapeutic agents. Its versatility and reliability have made it a standard tool in both academic and industrial research environments.

Advantages (TCI brochure)

Selectively binds drug binding site II on HSA
Activity markedly lower with FA+ HSA, so FA- HSA is recommended

TCI brochures (PDF)

Fluorescent Probes for the Characterization of Two Specific Drug Binding Sites on HSA 2025-04-01 · p. 1
Boron Compounds 2025-10-07 · p. 28
Reagents for Biological Research 2025-03-11 · p. 26

Related TCI products

Albumin Binding Assays – This compound is ideal for assessing how drugs bind to albumin, which is crucial for understanding drug distribution and metabolism in the body.
Pharmaceutical Development – It supports the evaluation of drug stability and efficacy by simulating physiological conditions in vitro.
Drug Discovery Research – It aids in identifying potential drug candidates by analyzing their interaction with albumin, a key transport protein.
Biochemical Studies – It is used to investigate molecular interactions that influence drug behavior in biological systems.
Analytical Testing – Its high purity and stability make it suitable for use in analytical procedures requiring accurate and reproducible results.

From the TCI brochure

Albumin binding assay
Confirming drug binding to site II on HSA

Brand	TCI
CAS number	1201643-08-4
Molecular formula	—
Purity	—
Category	Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Albumin Binding Agents
Pack sizes	—
Physical form	—
Storage	Store in a cool, dry place away from direct sunlight

Data from the TCI brochure

Konsentrasi probe pada uji inhibisi	80 µM (HSA (FA-) 5 µM, 1% DMSO in 10mM phosphate buffer pH 7.2-7.5, 20-25°C, 30 menit)
Konsentrasi probe pada dose response	20 µM (dose response HSA (FA+/-), 20-25°C, 30 menit)
Emission	585 nm (plate reader, excitation 365 nm)

Source: TCI brochure LL062 (2025-04-01)

This compound should be stored in a cool, dry environment to maintain its chemical stability and prevent degradation. It is recommended to keep it in a sealed container to minimize exposure to moisture and air. Since it is used in laboratory settings, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure safe handling. The material should be stored away from incompatible substances to avoid any potential chemical reactions. Proper labeling of containers is essential for safe storage and easy identification. Regular monitoring of storage conditions is advised to ensure the integrity of the compound remains unaffected over time.

References cited in the TCI brochure

Jun Cheng Er. Fluorescent Dye Cocktail for Multiplex Drug-Site Mapping on Human Serum Albumin ACS Combinatorial Science, 2013. doi:10.1021/co400060b