Dansylsarcosine Cyclohexylammonium Salt [for Albumin binding assay] TCI D5883

Name: TCI D5883 2733745-64-5 Dansylsarcosine Cyclohexylammonium Salt [for Albumin binding assay]
Brand: TCI
SKU: TCI2510D588326872
Price: 2038050.0 IDR
Availability: InStock

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Berat 25mg 100mg

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Description

TCI D5883 Dansylsarcosine Cyclohexylammonium Salt is a fluorescent reagent prepared specifically for albumin binding assays. The molecule combines a dansyl group — a naphthalene sulfonamide-derived fluorophore well known for its sensitivity to the surrounding environment — with a sarcosine unit, and is supplied as the cyclohexylammonium salt for easier handling. In routine laboratory practice, the compound serves as a marker probe that occupies one of the drug binding sites on serum albumin, so that the binding strength of a test compound can be estimated by measuring competitive displacement of the probe.

The characteristic that makes this reagent valuable is the fluorescence behaviour of the dansyl group, which depends strongly on the polarity of its environment. When free in aqueous solution the probe fluoresces relatively weakly, but once bound inside a hydrophobic pocket of the protein its intensity rises sharply and its emission maximum shifts. This clear change in signal is what allows measurements to be carried out without radioactive labelling and without physical separation of the bound and free fractions. The cyclohexylammonium salt form helps keep the material as a solid that is convenient to weigh and dispense.

In Indonesian laboratories, reagents of this type are used in pharmaceutical development and drug discovery research groups, in university and institutional research laboratories, and in analytical facilities equipped with fluorescence instrumentation. They are typically ordered in small quantities appropriate to assay-scale work, kept under controlled conditions between experiments, and handled as part of a documented reagent inventory so that the same probe material can be used consistently across a series of binding studies.

Laboratory Applications

Competitive albumin binding assays — the probe occupies a defined drug binding site on serum albumin, so displacement by a test compound gives a direct, quantifiable measure of relative binding affinity.
Fluorescence-based plasma protein binding screening — the strong intensity change on binding lets samples be read directly in a fluorimeter or plate reader, without separating bound and free fractions.
Drug discovery lead characterisation — early estimates of albumin binding help research groups interpret how strongly candidate molecules associate with plasma protein during compound selection and prioritisation.
Binding site mapping studies — because the dansylsarcosine probe reports on one particular site, it can be used to distinguish which region of albumin a test compound interacts with preferentially.
Fluorescence probe method development — the environment-sensitive dansyl group makes this reagent a useful reference material when establishing, validating, or troubleshooting protein binding assay protocols in the laboratory.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 2733745-64-5
Product code: D5883
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Albumin Binding Agents
Physical form: solid, supplied as the cyclohexylammonium salt
Pack sizes: research-scale packs; please confirm the currently available pack size when ordering
Storage: keep in the closed original container under the conditions stated on the manufacturer's label

Handling and Storage

Store the reagent in its original tightly closed container, protected from light and moisture, and follow the storage conditions printed on the manufacturer's label and safety data sheet. Because the compound is a fluorescent probe, prolonged exposure to light should be avoided so that its optical performance is not affected. Prepare solutions in clean amber glass or other light-protecting vessels, and label all working dilutions with contents and preparation date. Weigh and transfer the solid in a well-ventilated area or fume hood, wearing gloves, a laboratory coat, and eye protection. Avoid generating dust, avoid contact with skin and eyes, and wash hands after handling. Dispose of residues and contaminated consumables through the laboratory's chemical waste procedure rather than the general drain or bin.