TCI D6181 Desipramine Hydrochloride is the hydrochloride salt form of desipramine, a tricyclic compound widely known in pharmacology as a norepinephrine reuptake inhibitor. In this catalogue the compound is listed as a pharmaceutical research reagent for experimental use, not as a medicinal preparation for human administration. In the laboratory it serves as a pharmacological tool, meaning a molecule whose target and mechanism of action are well documented and which can therefore be used to test, calibrate, or validate the experimental systems that researchers are developing.
The characteristic that makes this compound a preferred choice is its relatively high selectivity for the norepinephrine transporter compared with other monoamine transporters, which allows researchers to separate the contribution of the noradrenergic pathway from the serotonergic pathway within a single experiment. The hydrochloride salt form also brings practical advantages: solubility in water and aqueous buffers is considerably better than that of the free base form, while the solid material is more stable and easier to weigh out accurately. The compound is additionally used as a reference substrate in metabolism studies.
In Indonesian laboratories this reagent is typically handled within university pharmacology and biochemistry departments, research institutes, and analytical service laboratories that require a well-characterised reference compound. Because the material is supplied strictly for experimental work, it is normally requested by laboratories that already operate defined procedures for controlled research chemicals, including recorded weighing, documented stock preparation, and internal approval of the experimental protocol before the material is drawn from storage.
TCI brochures (PDF)
- Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 26
- Norepinephrine transporter studies: the compound acts as a well-documented reuptake inhibitor, giving researchers a dependable reference point when characterising transporter activity in their own assay systems.
- Pathway discrimination experiments: its relatively high selectivity for the norepinephrine transporter over other monoamine transporters lets investigators separate noradrenergic from serotonergic contributions within one experimental design.
- Assay validation and system calibration: because target and mechanism are already established in the literature, the material is suitable for confirming that a newly built experimental setup responds as expected.
- Drug metabolism research: the compound is widely used as a reference substrate in metabolism studies, supporting work where a well-characterised tricyclic molecule is required.
- Aqueous buffer-based pharmacological screening: the hydrochloride salt dissolves readily in water and aqueous buffers, making stock solution preparation straightforward for routine in vitro screening protocols.
| Brand | TCI |
|---|---|
| CAS number | 58-28-6 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use) |
| Pack sizes | available in the catalogue pack sizes offered by TCI for this product code (D6181) |
| Physical form | supplied as a solid hydrochloride salt |
| Storage | store according to the manufacturer's stated conditions on the product label and accompanying documentation |
Store the material in its original tightly closed container, kept dry and protected from light and moisture, and follow the storage conditions stated by the manufacturer on the product label. Glass containers with well-sealing closures are appropriate for both the supplied solid and any prepared stock solutions. Handle the compound in a fume hood or a well-ventilated area, wearing gloves, a laboratory coat, and eye protection, and avoid generating or inhaling dust during weighing. Because this material is intended for experimental use only and not for human administration, keep it clearly labelled, segregated from clinical or food-grade materials, and dispose of residues and contaminated consumables through the laboratory's chemical waste route.
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Product Categories
- Biochemicals and ReagentsPharmaceutical Research Reagents (for Experimental Use)Neurotransmitter Agent Ingredients (for Research and Experimental Use)
- Biochemicals and Reagents
- Pharmaceutical Development and Drug Discovery ResearchPharmaceutical Research Reagents (for Experimental Use)Neurotransmitter Agent Ingredients (for Research and Experimental Use)
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