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Description
2-Fluoro-5-methoxybenzonitrile, supplied under TCI catalogue code F0642, is a fluorinated aromatic building block that carries a nitrile group, a methoxy group, and a fluorine atom in an ordered arrangement on a single benzene ring. The compound serves as an intermediate in organic synthesis, particularly in routes toward more complex molecules in medicinal chemistry and materials chemistry. Having three different substituents on one aromatic core gives researchers good control over the direction of subsequent reactions, while shortening the sequence of synthetic steps required to reach a desired target structure.
The property that makes this compound an attractive choice lies in the differing electronic character of its groups. The nitrile group is strongly electron-withdrawing and activates the position ortho to it, so the fluorine atom sitting at that position becomes susceptible to displacement by nucleophiles through the nucleophilic aromatic substitution mechanism. The methoxy group, by contrast, donates electrons into the ring and provides an electronic balance that influences the regioselectivity of downstream reactions. The nitrile group is itself a highly versatile functional handle, since it can be carried forward into a range of further transformations rather than being limited to a single outcome.
In Indonesian laboratories, this material is typically used in university and institutional research groups working on organic synthesis, as well as in industrial R&D units developing active pharmaceutical ingredient candidates and functional materials. It is generally ordered in research-scale quantities for route scouting, method development, and the preparation of analogue series, where a ready-made trisubstituted aromatic core removes the need to construct the substitution pattern in-house before the intended chemistry can begin.
Laboratory Applications
- Nucleophilic aromatic substitution studies, where the nitrile group activates the ortho fluorine so that amines, alkoxides, and thiolates can displace it under controlled and reproducible conditions.
- Medicinal chemistry intermediate preparation, providing a pre-configured trisubstituted aromatic core that shortens the synthetic sequence needed to reach more complex drug-candidate scaffolds.
- Heterocycle construction, in which the versatile nitrile functionality is carried forward into ring-forming transformations that build nitrogen-containing systems onto the existing aromatic framework.
- Materials chemistry research, where the combination of fluorine and methoxy substituents tunes the electronic character of aromatic units incorporated into functional organic materials.
- Analogue library synthesis, since the distinct electronic roles of the three substituents give predictable regioselectivity when preparing structurally related compounds for structure-activity comparison.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- Catalogue code: F0642
- CAS number: 127667-01-0
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard research-scale packaging; please confirm the currently offered sizes when ordering
- Storage note: keep tightly closed in the original container, protected from moisture and light
Handling and Storage
Store the compound in its original tightly closed container in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials. Amber glass or the supplier's original packaging is suitable, since it limits exposure to light and moisture. Handle the material inside a fume hood and wear standard personal protective equipment, including safety goggles, nitrile gloves, and a laboratory coat. Avoid inhalation of dust or vapour and avoid contact with skin and eyes. Because the compound bears a nitrile group, keep it away from strong acids, strong bases, and strong oxidising agents. Always consult the manufacturer's safety data sheet before use, and follow institutional procedures for chemical waste disposal.
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