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Description
TCI F0657 Fluocinolone Acetonide is a synthetic steroid compound belonging to the corticosteroid class, carrying two fluorine atoms along with an acetonide group on its steroid skeleton. As a laboratory material, this compound serves as a biochemical reagent and a comparison standard for research purposes, not as a medicinal preparation. In laboratory settings, compounds with this type of structure are used to study glucocorticoid receptor activity, to test cellular responses to anti-inflammatory compounds, and to act as a structural reference in the development and validation of analytical methods for corticosteroids.
The characteristics that make this compound a preferred choice are found in its fluorinated steroid skeleton, which is considerably more resistant to metabolic degradation than corticosteroids without fluorine substitution, thereby delivering a more consistent biological signal in long-duration experiments. The acetonide group, which caps two adjacent hydroxyl groups, adds lipophilic character that helps the compound cross cell membranes while simultaneously protecting the reactive portion of the molecule. In pure solid form, this compound is easy to weigh accurately and to dissolve in organic solvents such as dimethyl sulfoxide or ethanol when preparing working solutions.
In Indonesian laboratories, this material is typically handled in university research facilities, pharmaceutical laboratories, and analytical testing units that work with corticosteroid chemistry. It is commonly used by researchers preparing stock solutions for cell-based assays and by analysts who require a structural reference when establishing or verifying analytical procedures. Its solid form makes it practical for accurate weighing and routine handling in a standard laboratory workflow.
Laboratory Applications
Glucocorticoid receptor studies, because the fluorinated steroid skeleton resists metabolic degradation and therefore gives a more consistent biological signal across long experiments.
Cellular response testing to anti-inflammatory compounds, since the acetonide group increases lipophilicity and helps the molecule cross cell membranes during treatment.
Analytical method development for corticosteroids, where this compound functions as a defined structural reference against which separation and detection conditions can be established.
Analytical method validation work, because the material is supplied as a pure solid that can be weighed accurately and prepared reproducibly into reference solutions.
Preparation of stock solutions in organic solvents, as the compound dissolves in dimethyl sulfoxide or ethanol for downstream dilution into experimental working solutions.
Specifications
Brand: TCI
CAS number: 67-73-2
Category: Life Science > Biochemicals and Reagents > Steroids
Pack sizes: available in the packaging options listed for this catalogue item
Physical form: solid
Storage: keep in a closed original container under the conditions stated on the product label
Handling and Storage
Store this material in its original closed container, kept tightly sealed and protected from moisture and direct light, in a designated area for biochemical reagents. Use clean, dry spatulas and weighing vessels when handling the solid so that the material is not contaminated during transfer. Prepared solutions in dimethyl sulfoxide or ethanol should be kept in sealed, solvent-compatible vials and clearly labelled with the contents and preparation date. As with any steroid compound intended for research use, handle it as a laboratory chemical: wear a lab coat, gloves, and eye protection, weigh and transfer the powder where dust dispersion is controlled, and avoid direct skin contact or inhalation. Do not use this material for therapeutic purposes.
