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Description
TCI F0778 2-(2-Fluorophenyl)ethanol is an aromatic primary alcohol carrying a fluorine atom bound at the ortho position relative to the ethanol side chain. The compound serves as a building block in organic synthesis laboratories, particularly when researchers need to introduce a fluorinated phenylethyl fragment with a distinctive ortho substitution geometry. Its free hydroxyl group functions as a synthetic handle that can be converted into a wide range of other functional groups, while the aromatic carbon-fluorine bond is already installed from the outset, saving the fluorination steps that normally demand specialised reagents.
The characteristic that distinguishes this compound from its other isomers is the proximity of the fluorine atom to the side chain. The ortho position gives rise to local steric and electronic effects that can influence the conformation of the ethanol chain as well as the reactivity of the hydroxyl group in certain reactions. This effect is frequently exploited to direct selectivity or to stabilise the conformation of a target molecule through weak intermolecular interactions. In addition, the fluorine atom at the ortho position provides a very clear marker in fluorine nuclear magnetic resonance spectroscopy, so that monitoring the progress of a reaction becomes considerably more straightforward.
In Indonesian laboratories, this material is typically used in university and institutional research settings where organic synthesis, medicinal chemistry, and materials chemistry work is carried out. It suits research groups preparing fluorinated intermediates on a laboratory scale, as well as analytical laboratories that require a defined fluorinated aromatic alcohol as a starting material or comparison substance in method development work.
Laboratory Applications
Fluorinated intermediate synthesis: the pre-installed aromatic carbon-fluorine bond removes the need for separate fluorination steps that would otherwise require specialised and demanding reagents in the laboratory.
Medicinal chemistry building block work: the ortho-fluorinated phenylethyl fragment is introduced directly into target scaffolds, letting researchers explore how ortho substitution geometry changes molecular behaviour.
Functional group transformation studies: the free primary hydroxyl group acts as a versatile synthetic handle that can be converted into esters, ethers, halides, and other derivatives.
Selectivity and conformational control experiments: the local steric and electronic influence of the ortho fluorine can be used to direct reaction selectivity or stabilise target conformations.
Fluorine NMR method development: the ortho fluorine atom gives a very clear spectroscopic marker, making this compound useful for reaction monitoring and analytical method work.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 50919-06-7
Catalogue number: F0778
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in standard TCI research-scale packaging; please confirm the available size when ordering
Storage: store in a closed container under the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area away from direct sunlight, ignition sources, and incompatible materials, following the conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original supplier container or in a compatible, clearly labelled chemical container; organic alcohols are generally handled in glass. Handle the compound in a fume hood, wear safety glasses, gloves, and a laboratory coat, and avoid inhalation of vapours or contact with skin and eyes. Close the container promptly after use to limit moisture uptake and evaporation, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures.
