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Description
Guaiacol Glycerol Ether, better known as guaifenesin, is an ether formed by joining a guaiacol group to a glycerol chain, which gives the molecule a methoxy-substituted aromatic ring together with two aliphatic hydroxyl groups. This combination produces the characteristic intermediate polarity of the compound. In the laboratory it is used as a raw material for pharmaceutical research, as a reference standard in the analysis of cough preparations, and as a model compound in studies of formulation, dissolution, and stability of the widely marketed oral products that contain it.
The properties that make guaifenesin a preferred research material are its good solubility in warm water as well as in polar organic solvents such as ethanol, and its chromophore, which absorbs ultraviolet light and therefore makes the compound easy to detect with a UV detector on an HPLC system or with a spectrophotometer. The presence of a chiral centre on the glycerol chain makes it a popular test compound in the development of enantiomer separation methods using chiral columns. Its free hydroxyl groups also allow further chemical modification, for example esterification or etherification, in research on the synthesis of new derivatives.
In Indonesia, this material is widely sought by quality control laboratories in the pharmaceutical industry, where it supports the routine analytical and formulation work associated with oral cough preparations. It is equally relevant to academic and research laboratories working on separation science, method development, and synthetic derivatisation. Laboratories choose it because it behaves predictably across the common analytical techniques already established in Indonesian facilities, making it a practical everyday working material.
Laboratory Applications
- Pharmaceutical research raw material: the compound serves as a starting material for laboratory studies in pharmaceutical development, where its well-defined ether structure and reactive hydroxyl groups support controlled experimental work.
- Reference standard for cough preparation analysis: it acts as a comparison standard in the analysis of cough medicine formulations, since its UV-absorbing chromophore allows straightforward quantification against sample peaks.
- Formulation, dissolution, and stability studies: as a model compound it is used to examine how oral products behave during formulation, dissolution testing, and stability assessment under laboratory conditions.
- Chiral separation method development: the chiral centre on its glycerol chain makes it a popular test compound for developing and validating enantiomer separation methods on chiral chromatography columns.
- Synthesis of new derivatives: the free hydroxyl groups permit further chemical modification such as esterification or etherification, supporting research programmes aimed at preparing novel derivative compounds.
Specifications
- Brand: TCI
- Product code: G0159
- CAS number: 93-14-1
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes: available in the standard research pack sizes offered for this catalogue item; please confirm the required size when ordering.
- Storage note: store in a closed original container under the conditions stated on the manufacturer's label.
Handling and Storage
Store the material in its tightly closed original container, kept in a cool, dry, and well-ventilated place away from direct sunlight, moisture, and sources of heat or ignition. Chemically resistant glass or the supplied manufacturer packaging is suitable for storage, and containers should be clearly labelled and resealed immediately after each use to limit exposure to atmospheric humidity. Handle the compound in a well-ventilated laboratory area using standard personal protective equipment, including a laboratory coat, safety glasses, and suitable gloves. Avoid the generation of dust, avoid contact with skin and eyes, and always consult the manufacturer's safety data sheet before use and prior to disposal.
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