L-Histidine Hydrochloride Monohydrate is the hydrochloride salt form of the amino acid L-histidine, crystallised with one molecule of water. This salt modification was developed to improve solubility behaviour and ease of handling without altering the molecular framework or the stereochemical configuration of the parent amino acid. In the TCI catalogue the product carries the code H0150 and is grouped within the peptide chemistry product line. In the laboratory the material is widely used for preparing histidine buffers, as a component of cell culture media, as a formulation ingredient in model therapeutic protein preparations, and as a reagent in coordination chemistry research and protein purification work.
The advantage of the hydrochloride monohydrate form lies in its water solubility, which is considerably better than that of free histidine, so that high-concentration solutions can be prepared quickly without excessive heating or complicated pH adjustment. The defined content of water of crystallisation gives the compound a consistent molecular weight, which makes molarity calculations more reliable. The solid itself is relatively stable, does not cake easily, and is straightforward to weigh out. The buffering character contributed by the imidazole ring is fully retained, making this form a popular choice for biopharmaceutical formulation buffers.
In Indonesian laboratories these characteristics matter in practical daily work. Analysts preparing histidine buffer systems, culture media, or protein formulation studies benefit from a material that dissolves readily at ambient conditions and weighs reproducibly, since buffer preparation is often repeated across many batches. The catalogue code H0150 and the peptide chemistry classification make the item straightforward to identify and reorder for teams running routine protein and buffer preparation work.
- Histidine buffer preparation — the retained imidazole ring buffering character and high water solubility allow buffer solutions to be made up rapidly without excessive heating or complicated pH adjustment.
- Cell culture media formulation — the material serves as a histidine source component in culture media, where its consistent molecular weight supports reliable molarity calculations during media makeup.
- Model therapeutic protein formulation — the hydrochloride monohydrate form is a popular choice for biopharmaceutical formulation buffers because its buffering behaviour and dissolution properties are retained from the parent amino acid.
- Coordination chemistry research — L-histidine's molecular framework and stereochemical configuration are unchanged by the salt modification, making the compound a suitable reagent for coordination studies.
- Protein purification work — the material is used as a reagent in purification procedures, where rapid preparation of high-concentration solutions without excessive heating is a practical benefit.
| Brand | TCI, catalogue code H0150 |
|---|---|
| CAS number | 5934-29-2 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Chemical Biology > Peptide Chemistry |
| Pack sizes | available in the pack sizes listed for this catalogue item |
| Physical form | crystalline solid containing one molecule of water of crystallisation; relatively stable, not prone to caking, and easy to weigh |
| Storage | store the container closed and protected from moisture so that the defined water of crystallisation content and the reliability of molarity calculations are preserved |
Store the product in its original tightly closed container, kept dry and protected from moisture uptake, since the defined content of water of crystallisation is what makes the molecular weight consistent and molarity calculations dependable. Glass or chemically compatible plastic containers with well-sealing closures are suitable, and containers should be reclosed promptly after each weighing. Handle the solid in a clean, dry working area using dedicated dry spatulas to avoid cross-contamination between batches. General laboratory precautions apply: wear a laboratory coat, safety glasses, and suitable gloves, avoid raising dust during transfer, and label all prepared solutions clearly with the concentration and preparation date. Because solutions of this material dissolve readily without excessive heating, prepare them at ambient conditions wherever possible.
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