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Description
Homatropine Hydrochloride is the hydrochloride salt of homatropine, a semisynthetic tropane alkaloid that acts as a muscarinic receptor antagonist. The compound is the salt-form counterpart of homatropine hydrobromide, sharing the same active molecular skeleton, and therefore offers an option for researchers who require a chloride counter-ion to match the buffer system or analytical method in use. Within the TCI catalogue this product carries the code H0156 and is grouped under the alkaloid line for life science work, where it serves as a reference antagonist for cholinergic studies.
The hydrochloride form is generally chosen because its solubility in water is very good, because it introduces no bromide ion that could interfere with certain analytical techniques such as ion chromatography or mass-based detection, and because it yields a solid that is easy to weigh and handle at the bench. Its competitive antagonism at muscarinic receptors is reversible, which suits experiments that require tissue responses to recover after washout. Adequate storage stability and predictable dissolution behaviour further support its use in routine and comparative work.
In Indonesian laboratories the material fits naturally into pharmacological research on cholinergic receptors, quality testing of raw materials, and laboratory teaching activities. University pharmacology and pharmacy departments, research institutes, and quality control units working with tropane alkaloids can use it where a well-defined muscarinic antagonist is needed. The predictable handling characteristics make it practical for settings where the same preparation must be repeated reliably by different operators across teaching and research sessions.
Laboratory Applications
Cholinergic receptor pharmacology research: serves as a reversible competitive muscarinic antagonist, allowing tissue or cell responses to be blocked and then recovered after washout in repeated-measurement protocols.
Raw material quality testing: functions as a defined alkaloid reference in quality control of incoming materials, where consistent solid form and predictable dissolution support reproducible sample preparation.
Laboratory teaching activities: suitable for pharmacology practical classes demonstrating muscarinic receptor antagonism, since the solid is easy to weigh and dissolves readily for student-prepared solutions.
Analytical method development avoiding bromide interference: the chloride counter-ion prevents bromide-related interference in techniques such as ion chromatography or mass-based detection during method work.
Buffer-compatible solution preparation: the excellent water solubility of the hydrochloride form lets researchers match existing buffer systems without introducing a counter-ion that conflicts with the assay.
Specifications
Brand: TCI
CAS number: 637-21-8
Catalogue code: H0156
Category: Life Science > Biochemicals and Reagents > Alkaloids
Physical form: solid, suitable for direct weighing
Storage: store under conditions appropriate for the material; adequate storage stability under normal laboratory conditions
Handling and Storage
Store the container closed and protected from moisture, since the hydrochloride salt is highly water soluble and can absorb atmospheric humidity if left open. Keep the material in its original tightly sealed container, or transfer it to a clean, well-labelled glass or chemically compatible vial with a secure closure. Weigh and handle the solid in a well-ventilated area or fume hood to avoid inhalation of dust, and wear standard laboratory personal protective equipment including gloves, a laboratory coat, and eye protection. As with any pharmacologically active alkaloid, avoid direct skin and eye contact, avoid generating airborne powder, and wash hands thoroughly after handling. Prepare solutions immediately before use where possible, label all dilutions clearly, and follow institutional procedures for the disposal of alkaloid-containing waste.
