4-Methyl-1-acetoxycalixarene [mixture of [6] and [8]] (contains 5-10% Acetone) TCI H0889

4-Methyl-1-acetoxycalixarene [mixture of [6] and [8]] is a calixarene-based supramolecular reagent, a family of bowl-shaped macrocycles built from phenol units joined through methylene bridges. This TCI product is supplied as a mixture of the six- and eight-membered ring homologues in which the phenolic hydroxyl groups have been acetylated, and it contains 5–10% acetone as stated in the product name. In the laboratory, calixarenes serve as molecular hosts capable of trapping guest ions or molecules within their cavity, which makes them an important tool for molecular recognition chemistry.

The characteristics that lead researchers to select this material are its well-defined cavity geometry and the presence of acetoxy groups as chemical handles. The macrocyclic cavity provides a confined environment that is selective for the size and shape of the guest species, while the acetoxy groups protect the phenols, modify the solubility of the compound in organic solvents, and can be hydrolysed back to the free phenols when required. Because the product is a mixture of the six- and eight-unit rings, it spans a broader range of cavity sizes and is therefore well suited to early-stage screening when the researcher has not yet established which ring size performs best.

In Indonesian laboratories, reagents of this type are typically used in university and institutional research groups working on supramolecular chemistry, host–guest systems, molecular recognition, and the preparation of functionalised macrocyclic scaffolds. The mixed-homologue format is practical for exploratory synthetic work and method development, where several cavity sizes can be evaluated before a single ring size is committed to. It is handled as a standard research-grade synthetic reagent on the bench rather than as a routine analytical standard.

• Host–guest complexation studies: the defined macrocyclic cavity accommodates guest ions and small molecules, allowing binding behaviour to be probed under controlled laboratory conditions.
• Molecular recognition research: the size- and shape-selective cavity makes this reagent useful for investigating how confined environments discriminate between structurally related guest species.
• Cavity-size screening experiments: because the product combines the six- and eight-membered homologues, it lets researchers survey a wider size range before selecting one ring.
• Synthesis of functionalised calixarene derivatives: the acetoxy groups act as chemical handles that can be hydrolysed back to free phenols for further selective modification.
• Solubility-controlled supramolecular work in organic media: acetylation of the phenolic hydroxyls alters solubility, easing use of the macrocycle in organic solvent systems.

• Product code: H0889
• Composition: mixture of the [6] and [8] ring homologues; contains 5–10% acetone

Store the reagent in its original tightly closed container, in a cool, dry and well-ventilated area away from heat, ignition sources and direct sunlight, following the storage conditions given on the manufacturer's label and Safety Data Sheet. Because the material contains 5–10% acetone, treat it as a solvent-wetted solid: avoid open flames and keep the container closed when not in use to limit solvent loss and vapour release. Handle in a fume hood using gloves, safety glasses and a laboratory coat, weigh out portions promptly to minimise exposure to air and moisture, and use clean, dry chemically compatible glass or polyethylene containers for transfer and temporary storage. Dispose of residues and contaminated consumables through the laboratory's chemical waste procedures.

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