3-Hydroxy-5-methylisoxazole TCI H1348

3-Hydroxy-5-methylisoxazole is a five-membered heterocyclic compound containing adjacent nitrogen and oxygen atoms within an isoxazole ring, carrying a hydroxyl group at the three position and a methyl group at the five position. The compound is more widely known in agricultural science under the common name hymexazol. In the laboratory it serves two roles at once: as a heterocyclic building block for organic synthesis, and as a reference material in research and analysis concerned with agriculturally active compounds. Its availability in pure form makes it useful both for synthetic work and for analytical work that demands certain material identity.

The characteristics that lead chemists to select this compound are its isoxazole ring, which is stable yet remains open to functionalisation, together with a hydroxyl group that is appreciably acidic because of tautomerism with its carbonyl form. This acidity allows the compound to form salts, to undergo alkylation at either oxygen or nitrogen, and to participate in hydrogen bonding that influences both its solubility and its chromatographic behaviour. The isoxazole ring itself is a motif that appears frequently in pharmaceutical and agrochemical molecules, so the scaffold carries recognised value in exploratory synthetic programmes.

In Indonesian laboratories this material fits naturally into agricultural research institutes, university chemistry departments, and analytical service laboratories working on crop protection topics. It is used where a defined heterocyclic starting material is required for multi-step preparation, and equally where a well-characterised substance is needed to support identification and method development work. The supply of the compound in laboratory grade allows both teaching and research groups to work with consistent material across repeated experiments.

• Heterocyclic synthesis — the isoxazole ring provides a stable core that can be elaborated further, making this an efficient entry point for building more complex target molecules in multi-step routes.
• Agrochemical research — as the compound known commonly as hymexazol, it supports investigations into agriculturally active substances where the authentic material itself is the subject of study.
• Analytical reference work — the availability of the compound in pure form allows it to serve as a material of certain identity during method development and confirmation of analytical results.
• Derivatisation chemistry — the acidic hydroxyl group permits salt formation and alkylation at either oxygen or nitrogen, giving researchers several distinct handles for preparing structural analogues.
• Structure–activity exploration — because the isoxazole motif recurs across pharmaceutical and agrochemical molecules, the compound is well suited to programmes that probe how this scaffold influences biological behaviour.

• Product code: TCI H1348

Store this compound in a tightly closed container in a cool, dry, well-ventilated place, away from direct sunlight, heat sources, and incompatible materials. Original manufacturer packaging or a clean, chemically resistant container with a secure closure is appropriate, and containers should remain clearly labelled at all times. Handle the material in a fume hood, wearing safety glasses, gloves, and a laboratory coat, and avoid generating dust or inhaling any airborne particles. Because the hydroxyl group is acidic and capable of hydrogen bonding, keep the compound dry to preserve its condition. Refer to the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials through the laboratory's designated chemical waste route.

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