1,1,1,3,3,3-Hexafluoro-2-methyl-2-propanol [for HPLC] TCI H1861

Chemical Identity

CAS No.: 1515-14-6
Purity: >98.0%(HPLC)

Rp 3.630.900,00

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Berat 5g

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↓ Unduh SDS / MSDS (PDF resmi TCI)

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TCI H1861 is 1,1,1,3,3,3-Hexafluoro-2-methyl-2-propanol supplied in a grade intended for HPLC work. It is a fluorinated tertiary alcohol used as a solvent and as a mobile phase additive in high performance liquid chromatography. In the analytical laboratory, fluoroalcohols of this class serve to modify the retention behaviour and peak shape of polar and ionic analytes that are difficult to separate using conventional organic solvents. The 5 g pack allows a laboratory to prepare measured additive stock solutions without leaving surplus material that could degrade or evaporate during long storage on the analytical solvent shelf.

The characteristic that makes this material a preferred choice is the hexafluoro substitution attached to the propanol skeleton, which gives it electronic properties markedly different from those of an ordinary alcohol. Fluorine substitution increases the acidity of the hydroxyl group while reducing the nucleophilic character of the molecule, and the methyl group on the quaternary carbon adds steric hindrance that leaves the molecule relatively inert toward the analyte. The combination produces a solvent of high polarity but low coordinating power, a condition that is very useful when the analyst wishes to suppress unwanted interactions in the separation system.

In Indonesian laboratories, this reagent is typically found in analytical chemistry and chromatography facilities where method development work is carried out on polar or ionic compounds. It is normally kept alongside other HPLC-grade solvents and additives, drawn on in small measured volumes for mobile phase preparation rather than used in bulk. The small pack format fits the working pattern of university, government and industrial analytical laboratories that run chromatographic methods intermittently rather than continuously.

Advantages (TCI brochure)

Quality-guaranteed absorbance near the wavelengths for oligonucleotide analysis

TCI brochures (PDF)

Buffers and Additives for Oligonucleotide LC Analysis 2025-06-03 · p. 1
Oligonucleotide Synthesis Reagents 2025-07-24 · p. 2
Nucleosides, Nucleotides, Nucleic Acids and Related Reagents 2026-03-23 · p. 16

Related TCI products

Mobile phase additive preparation for HPLC methods, where small measured quantities of the fluoroalcohol are introduced to adjust the retention behaviour of analytes that resist separation on conventional organic solvent systems.
Peak shape improvement for polar analytes, since the high polarity combined with low coordinating power helps suppress unwanted interactions that broaden or tail chromatographic peaks during analysis.
Separation of ionic compounds, where the increased acidity of the fluorinated hydroxyl group alters analyte behaviour in ways that conventional alcohols used as chromatographic solvents cannot reproduce.
Chromatographic method development work, where the analyst screens solvent and additive combinations and needs a fluoroalcohol whose steric hindrance keeps it relatively inert toward the analyte itself.
Preparation of additive stock solutions in analytical laboratories, with the 5 g pack sized so that measured stock can be made up without leaving excess material on the shelf.

From the TCI brochure

Mobile phase modifier for LC-MS analysis of oligonucleotides

Brand	TCI
CAS number	1515-14-6
Molecular formula	—
Purity	—
Category	Analytical Chemistry > Analytical Reagents > Chromatography Reagents and Solvents
Pack sizes	5 g
Physical form	—
Storage	keep in the closed original container on the analytical solvent shelf, away from conditions that promote evaporation or degradation

Grade: for HPLC

Store the material in its original tightly closed container on the analytical solvent shelf, in a cool, well ventilated area away from heat and ignition sources. Because the compound is volatile, containers should be resealed promptly after each withdrawal to limit evaporative loss and to protect the remaining material over long storage periods. Handle in a fume hood using appropriate personal protective equipment, including gloves, eye protection and a laboratory coat, and dispense with clean dry glassware or syringes to avoid contaminating a reagent intended for chromatographic use. Follow the supplier safety data sheet and local laboratory waste procedures for disposal of residues and rinsings.

References cited in the TCI brochure

Babak Basiri. The Role of Fluorinated Alcohols as Mobile Phase Modifiers for LC-MS Analysis of Oligonucleotides Journal of the American Society for Mass Spectrometry, 2016. doi:10.1007/s13361-016-1500-3