Isobutyric Acid from TCI (product code I0103), also known as 2-methylpropanoic acid, is a short-chain carboxylic acid with a methyl branch. TCI lists it under non-heterocyclic building blocks, and organic synthesis laboratories use it as an important starting material. Its carboxylic acid group can be converted into esters, amides, acyl chlorides, and anhydrides, so one bottle can feed several synthetic routes. Isobutyric acid is also one of the short-chain fatty acids, and it is studied in microbiology, nutrition, and fermentation technology.
Isobutyric acid is a liquid with a sharp, characteristic odor. Because it is a liquid, it is easy to measure with a pipette or graduated cylinder when setting up synthesis reactions. The methyl branch at the alpha position creates a steric effect that straight-chain butyric acid does not have. Researchers use this difference when they need to introduce an isobutyryl group into a target molecule. Its esters are known for their fruity aromas, which makes the compound relevant to flavor chemistry. It comes in 25 mL and 500 mL packs, so laboratories can buy a small amount for exploratory research or a larger amount for routine use.
In Indonesia, university organic chemistry laboratories use isobutyric acid in esterification practicals, where students learn to convert a carboxylic acid into an ester and observe the result. Research groups working on synthesis use it to build molecules that need an isobutyryl group. Laboratories that study microbiology, nutrition, and fermentation also use it as a reference compound for short-chain fatty acids. The two pack sizes cover both small teaching or research batches and regular consumption in busy laboratories.
TCI brochures (PDF)
- Colloidal Quantum Dot (QD) Research Reagents 2026-05-21 · p. 5
- Esterification practicals: Isobutyric acid is a simple, well-understood carboxylic acid, so students can use it to learn ester formation in university organic chemistry courses.
- Introducing isobutyryl groups: Its alpha methyl branch gives it a distinct steric profile, so chemists use it when a target molecule needs an isobutyryl group instead of a straight-chain acyl group.
- Preparing carboxylic acid derivatives: Its carboxyl group can be converted into amides, acyl chlorides, and anhydrides, which makes it a flexible non-heterocyclic building block for multistep synthesis.
- Flavor chemistry research: The esters of isobutyric acid are known for their fruity aromas, so researchers use it to study and prepare aroma compounds for flavor applications.
- Short-chain fatty acid studies: Isobutyric acid is one of the short-chain fatty acids, so it is useful as a reference compound in microbiology, nutrition, and fermentation technology research.
| Brand | TCI (product code I0103) |
|---|---|
| CAS number | 79-31-2 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | 25 mL and 500 mL |
| Physical form | Liquid with a sharp, characteristic odor |
| Storage | Keep tightly closed in a cool, well-ventilated area, following the manufacturer's label and Safety Data Sheet |
Keep isobutyric acid in its original, tightly closed container. Store it in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and incompatible materials such as strong bases and oxidizing agents. Because it has a sharp, pungent odor, open and dispense it inside a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat when handling it, and avoid contact with skin and eyes or breathing in its vapor. Use clean glass pipettes or graduated cylinders to measure it. Label secondary containers clearly, and close the bottle promptly after each use. Before working with the product, read the Safety Data Sheet from the manufacturer, and dispose of waste according to your institution's chemical waste procedures.
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