4-Methylmorpholine TCI M0370

TCI M0370 4-Methylmorpholine is a heterocyclic tertiary amine built around a six-membered morpholine ring that contains both a nitrogen atom and an oxygen atom, with a methyl group bonded to the ring nitrogen. The presence of the oxygen atom within the ring lowers the basicity of the compound compared with ordinary aliphatic amines, so the material behaves as a base strong enough to scavenge acid yet not so aggressive that it drives unwanted side reactions. In organic synthesis laboratories it is widely used as a neutralising base and as an auxiliary solvent across a range of bond-forming reactions.

The property that makes this compound particularly valued is its role as a sterically hindered base that is not strongly nucleophilic. Because of this combination, it can absorb the hydrogen halide generated during a reaction without itself attacking the electrophilic centre that is being transformed. This behaviour is most prominent in the mixed anhydride method used in peptide synthesis, where the compound works together with an alkyl chloroformate to activate the carboxyl group. Its physical form is a liquid that mixes readily with many organic solvents, which makes it straightforward to measure out and introduce into a reaction mixture.

In Indonesian laboratories the material is typically found in organic synthesis groups, peptide chemistry work, and pharmaceutical intermediate preparation at universities, research institutes, and industrial development units. Because it functions both as an acid scavenger and as a co-solvent, a single reagent covers several needs on the bench, which suits laboratories that keep a compact chemical inventory. Its liquid form supports routine dispensing by pipette or syringe into reactions being set up under standard bench conditions.

• Peptide synthesis by the mixed anhydride method, where the compound pairs with an alkyl chloroformate to activate the carboxyl group while neutralising the acid released during coupling.
• Acid scavenging in bond-forming reactions, since its moderate basicity captures hydrogen halide by-products without attacking the electrophilic centre that the chemist intends to react.
• Heterocyclic building block work, where the morpholine ring bearing nitrogen and oxygen serves as a structural unit incorporated into larger target molecules during multi-step synthesis.
• Use as an auxiliary solvent in organic reactions, because the liquid mixes readily with many organic solvents and helps keep reagents and intermediates in solution throughout.
• Pharmaceutical intermediate preparation, where a non-nucleophilic hindered base is required so that sensitive electrophilic substrates survive the reaction without competing attack from the base itself.

• Chemical name: 4-Methylmorpholine (catalogue code M0370)

Store the container tightly closed in a cool, dry, well-ventilated area away from heat sources, open flame, and direct sunlight, and keep it separated from strong acids and strong oxidising agents. Keep the material in its original manufacturer container or in a compatible sealed glass bottle, since the liquid is volatile and amine vapours escape easily from loosely closed vessels. Dispense and transfer inside a fume hood, and wear safety goggles, chemical-resistant gloves, and a laboratory coat. Return the bottle to its designated storage cabinet promptly after use and consult the manufacturer safety data sheet before handling.

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