TCI M2324 Methylamine (ca. 9% in Isopropyl Alcohol, ca. 2 mol/L) is a solution of methylamine at approximately two molar concentration, prepared in isopropyl alcohol as the solvent. Like its ethanolic counterpart, this preparation answers the practical difficulty of handling methylamine, which is a gas in its free state: rather than working with gas cylinders or condensation apparatus, a researcher simply draws a measured volume with a syringe to obtain the desired number of moles. In the laboratory it serves a dual role as a reagent for installing the N-methylamino group and as an amine base, while the choice of isopropyl alcohol as solvent provides an additional option for cases where the solvent itself influences how a reaction proceeds.
The advantage that leads chemists to select this particular variant lies in the character of isopropyl alcohol as a secondary alcohol, which is more sterically hindered than ethanol. When the substrate is an ester, a primary alcohol solvent may participate in the reaction and exchange groups through transesterification; secondary alcohols are generally far more sluggish in reactions of this kind, so the risk of unwanted side products is suppressed. In addition, isopropyl alcohol has a slightly different polarity and dissolving power, which can at times give better substrate solubility or improved selectivity. The predetermined concentration keeps stoichiometric calculation straightforward.
In Indonesian laboratories, this solution is typically found in synthetic organic chemistry groups at universities and research institutes, as well as in pharmaceutical and fine chemical development laboratories where N-methylated structures are common targets. Because it arrives as a ready-made solution of known molarity, it suits settings that do not maintain dedicated gas-handling infrastructure, allowing smaller research groups to run methylamination chemistry with ordinary syringe technique and standard inert-atmosphere glassware.
TCI brochures (PDF)
- Safely Handleable Volatile Solutions 2024-05-02 · p. 1
Related TCI products
- TCI M2323 74-89-5 Methylamine (ca. 9% in Ethanol, ca. 2mol/L)
- TCI M2108 74-89-5 Methylamine (ca. 7% in Tetrahydrofuran, ca. 2mol/L)
- TCI M1016 74-89-5 Methylamine (40% in Methanol, ca. 9.8mol/L)
- TCI D4198 124-40-3 Dimethylamine (ca. 11% in Isopropyl Alcohol, ca. 2mol/L)
- TCI M0137 74-89-5 Methylamine (ca 40% in Water, ca 12mol/L)
- TCI T2893 75-50-3 Trimethylamine (ca. 25% in Isopropyl Alcohol, ca. 3mol/L)
- N-methylation of organic substrates: the solution delivers methylamine in measured molar amounts by syringe, so the introduction of an N-methylamino group can be carried out with straightforward stoichiometric control rather than gas-handling equipment.
- Amide formation from esters: the sterically hindered secondary alcohol solvent is far less prone to transesterification than a primary alcohol, reducing the chance of solvent-derived side products when esters are converted with methylamine.
- Use as an amine base in synthetic sequences: methylamine functions as a base in this preparation, and the known molar concentration lets a researcher add a defined equivalent of base without preparing a separate stock solution.
- Solvent-sensitive reactions requiring an alternative medium: isopropyl alcohol offers a slightly different polarity and dissolving power from ethanol, giving an additional option where the solvent character itself affects reaction outcome or selectivity.
- Preparation of N-methylated intermediates in pharmaceutical and fine chemical development: the ready-made two-molar solution supports repeatable small-scale runs where N-methylamino groups are a recurring structural target.
| Brand | TCI |
|---|---|
| CAS number | 74-89-5 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Synthetic Reagents > Acids, Bases [Synthetic Reagents] |
| Pack sizes | as listed by TCI for this catalogue item; storage in a cool place away from heat and ignition sources |
| Physical form | solution, methylamine at ca. 9% in isopropyl alcohol (ca. 2 mol/L) |
| Storage | — |
- Product code: M2324
Store the solution in a cool, well-ventilated place, kept tightly closed in its original manufacturer container and away from heat, sparks, open flame, and other ignition sources, since the isopropyl alcohol solvent is flammable. Handle it inside a functioning fume hood, as methylamine is volatile and has a strong odour. Wear chemical-resistant gloves, safety goggles, and a laboratory coat, and withdraw portions with a clean dry syringe to limit exposure to air and moisture. Close the container immediately after use, keep it separated from strong acids and oxidising agents, and follow the manufacturer's safety data sheet together with your institution's chemical waste procedures for disposal.
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