4-(1-Methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoic Acid TCI M3886

Chemical Identity

CAS No.: 31349-48-1
Purity: >97.0%(HPLC)(T)

Rp 4.028.850,00

~~Rp 2.832.900,00~~ Rp 4.028.850,00

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TCI M3886 4-(1-Methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoic Acid is a heterocyclic building block constructed on a benzimidazole core, carrying a methyl group on the one-position nitrogen, a nitro group at the five-position, and a butanoic acid side chain at position two. This combination brings three elements together in a single molecule: a rigid fused aromatic core, a strong electron-withdrawing substituent, and a carboxylate group that serves as a coupling point. In the laboratory, the compound is used to assemble benzimidazole-based target molecules without having to construct the ring system from simpler starting materials.

The property that makes this material attractive is the dual function of its nitro group. Besides modulating the electron density of the ring, and thereby influencing reactivity and spectroscopic behaviour, the nitro group can be reduced to an aromatic amine, opening a route to acylation, sulfonylation, or further ring formation. The four-carbon butanoate chain acts as a flexible linker that provides adequate distance between the benzimidazole core and any group to be attached, a feature that proves useful in the design of conjugates, probes, and bifunctional molecules. The methylated nitrogen removes the tautomerism normally associated with an unsubstituted benzimidazole NH, giving a single, well-defined substitution pattern.

In Indonesian laboratories, this building block is typically handled in synthetic organic chemistry and medicinal chemistry groups at universities, government research institutes, and industrial R&D units. It is generally used in small-scale exploratory work: preparing amide libraries, testing coupling conditions, or developing intermediates for further study. Because it is supplied as a defined catalogue item, it suits research programmes where a consistent, reproducible starting material is required across repeated experiments and between different workers.

Related TCI products

Amide bond formation and coupling chemistry — the free carboxylic acid group is a direct handle for standard activation and coupling protocols, letting researchers attach amines without additional functional group manipulation on the core.
Synthesis of benzimidazole-based target molecules — the intact, pre-formed heterocyclic core removes the need to construct the ring from ortho-phenylenediamine precursors, shortening the route and reducing the number of purification steps.
Nitro group reduction to aromatic amine intermediates — the five-position nitro group can be converted to an aniline-type nitrogen, generating a second reactive site for acylation, sulfonylation, or subsequent cyclisation chemistry.
Preparation of bifunctional molecules and conjugates — the four-carbon butanoate linker provides spatial separation between the benzimidazole core and any appended group, which matters when steric crowding would otherwise interfere with binding or reactivity.
Structure-activity relationship studies in medicinal chemistry programmes — the defined, single-tautomer substitution pattern created by the N-methyl group gives an unambiguous scaffold for building and comparing analogue series.

Brand	TCI (Tokyo Chemical Industry)
CAS number	31349-48-1
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes	available in standard TCI research-scale catalogue pack sizes; please confirm the current options when ordering
Physical form	—
Storage	store in a cool, dry place in the tightly closed original container, away from light

Chemical Name: 4-(1-Methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoic Acid

Keep the material in its tightly closed original container in a cool, dry, well-ventilated place, protected from light and away from moisture and incompatible substances such as strong oxidising or reducing agents. Amber glass or the supplier's original packaging is suitable; transfer only what is needed for the work at hand and reseal promptly. Handle in a fume hood using safety glasses, gloves, and a laboratory coat, and avoid generating or inhaling dust when weighing the solid. Nitroaromatic compounds warrant particular care, so avoid heat, sparks, and mechanical shock. Consult the supplier's safety data sheet before first use, and dispose of residues and contaminated materials through authorised chemical waste channels in line with institutional procedures.

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