TCI N0080 Nicotine Bi-L-(+)-tartrate Dihydrate is the hydrated tartrate salt form of the alkaloid nicotine, prepared to provide a solid alternative that is far easier to handle than free base nicotine, which exists as a liquid. In the laboratory, this salt serves as a measurable source of nicotine for pharmacological research, for the preparation of test solutions at precise concentrations, and as a standard in analytical method development. Salt formation with L-(+)-tartaric acid produces a stable crystalline solid that can be weighed out accurately.
The principal characteristics that lead researchers to select this salt form are its improved stability against oxidation and darkening compared with the free base, together with the reduced risk of exposure through vapour, since the material is solid and not readily volatile. Its good solubility in water makes it straightforward to prepare aqueous solutions for biological assays without requiring an organic solvent as a carrier. The dihydrate status means that water molecules are bound within the crystal lattice, so dose calculations must account for the molecular mass of the hydrated salt rather than simply the mass of nicotine base — a detail that matters when experimental protocols are drawn up.
In Indonesian laboratories, this material is typically encountered in university pharmacology and pharmacy research groups, in analytical laboratories developing and validating methods, and in biochemical facilities that require a defined alkaloid source. Its solid crystalline form suits routine gravimetric work on an analytical balance, and its water solubility fits laboratories that prefer aqueous preparation over organic solvent systems for biological testing.
- Pharmacological research: serves as a measurable and reproducible source of nicotine, allowing researchers to dose experimental systems from an accurately weighed crystalline solid rather than a liquid base.
- Preparation of precise test solutions: the stable crystalline form can be weighed accurately on an analytical balance, supporting solution preparation at defined concentrations for quantitative experimental work.
- Analytical method development: functions as a standard during the development of analytical procedures, where a consistent and well-characterised nicotine source is required for reliable comparison.
- Aqueous biological assays: good water solubility allows aqueous solutions to be prepared directly for biological testing, avoiding the need for an organic solvent as a carrier in the assay system.
- Protocol and dosing calculations: the defined dihydrate composition allows researchers to calculate doses from the hydrated salt molecular mass, supporting accurate and documented experimental protocols.
| Brand | TCI |
|---|---|
| CAS number | 6019-06-3 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Alkaloids |
| Pack sizes | available in the pack sizes listed on this product page |
| Physical form | crystalline solid (hydrated tartrate salt of nicotine) |
| Storage | store according to the conditions stated on the manufacturer's label and safety data sheet |
Store the material in its original tightly closed container, kept in a cool, dry, well-ventilated place and protected from light and moisture, following the conditions given on the manufacturer's label and safety data sheet. Because this is a hydrated salt, containers should be closed promptly after use to preserve the defined water content on which dose calculations depend. Handle the solid in a fume hood or a well-ventilated area, wearing gloves, safety glasses, and a laboratory coat, and avoid generating dust during weighing. As an alkaloid preparation, it should be handled only by trained personnel, kept separate from incompatible materials, and disposed of in accordance with applicable laboratory waste procedures.
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