Naphazoline Hydrochloride TCI N0542

Chemical Identity

CAS No.: 550-99-2
PubChem: CID 11079·SID 87573865
Formula: C14H15ClN2
Molecular weight: 246.73 g/mol
Purity: >99.0%(T)
Reference databases: ChEBI·ChemSpider·ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride
SMILES: C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.Cl
InChIKey: DJDFFEBSKJCGHC-UHFFFAOYSA-N

Rp 1.008.000,00

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Naphazoline Hydrochloride is the hydrochloride salt of naphazoline, an imidazoline derivative known as an alpha-adrenergic receptor agonist. In pharmaceuticals, naphazoline is an established vasoconstrictor active ingredient used in eye drops and nasal drops to relieve redness and nasal congestion. TCI supplies this product as a pharmaceutical research reagent for experimental laboratory use. Laboratories use it as an analytical reference material, as a model compound in formulation studies, and as a pharmacological tool in receptor research. It suits pharmaceutical analysis work and biochemical research alike.

Researchers often choose the hydrochloride salt because it generally dissolves in water more readily than the free base. This makes it easier to prepare stock solutions for analytical work and in vitro assays. The imidazoline structure carries a naphthyl group that absorbs ultraviolet light, so the compound is easy to detect by UV spectrophotometry or HPLC with UV detection. Its activity at adrenergic receptors is well documented, which makes it a useful comparison compound in pharmacological studies of other sympathomimetic substances. TCI's consistent supply of research reagents helps laboratories keep their experimental results reproducible.

In Indonesia, Naphazoline Hydrochloride is relevant to pharmaceutical analysis laboratories at universities, research institutions, and quality control units that work on ophthalmic and nasal preparations. Pharmacy and chemistry students and lecturers can use it in practical classes and thesis research on drug analysis methods. Research groups studying adrenergic pharmacology can use it as a known reference agonist. Formulation laboratories can use it as a model active compound when developing and testing new delivery systems or analytical procedures.

TCI brochures (PDF)

Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 46

Related TCI products

Analytical reference material: the compound serves as a comparison standard when identifying and quantifying naphazoline in eye and nasal drop samples by UV spectrophotometry or HPLC.
HPLC method development and validation: its naphthyl chromophore gives a clear UV response, which helps when optimising separation conditions and checking method linearity, precision, and specificity.
Formulation studies: as a model water-soluble active compound, it is useful for evaluating new ophthalmic or nasal formulations, excipient compatibility, and release behaviour under laboratory conditions.
Adrenergic receptor research: because it is a well-known alpha-adrenergic agonist, it works as a pharmacological tool for probing receptor activity in in vitro experimental models.
Comparative pharmacology of sympathomimetics: its documented receptor activity makes it a reliable reference agonist when screening or characterising other sympathomimetic compounds in pharmacological studies.

Brand	TCI (product code N0542)
CAS number	550-99-2
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
Pack sizes	see the available options on the product listing
Physical form	—
Storage	keep the container tightly closed in a cool, dry place, and follow the TCI label and Safety Data Sheet

Chemical identity: hydrochloride salt of naphazoline, an imidazoline derivative

Store Naphazoline Hydrochloride in its original, tightly closed container in a cool, dry, well-ventilated area, away from direct light, moisture, and incompatible substances. Once stock solutions are prepared, keep them in clean, labelled glass or suitable inert containers and record the preparation date. Handle the compound only in the laboratory, by trained personnel, and wear appropriate personal protective equipment such as gloves, safety glasses, and a lab coat. Avoid inhaling dust and avoid contact with skin and eyes. This product is for experimental research use only and must not be used as a medicine or for human consumption. Always check the TCI Safety Data Sheet for specific hazard information, first aid measures, and disposal requirements before use.

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