1-Pentyne TCI P0068

1-Pentyne (CAS 627-19-0) is a five-carbon terminal alkyne that serves as an essential building block in organic synthesis within the chemistry laboratory. As a starting material, it acts as a stepping stone for constructing far more complex molecules through a range of reaction pathways, including metal-catalyzed cross-coupling, selective hydrogenation, hydroboration, and nucleophilic addition across the triple bond. The presence of a terminal acetylene group at the end of the chain makes the molecule highly responsive to a wide variety of reagents, allowing researchers to design chemical transformations with a high degree of selectivity.

In the organic laboratory, 1-Pentyne is frequently selected as a simple model alkyne for studying reaction mechanisms and as a precursor to higher-value compounds. The compound stands out because its terminal alkyne group bears a reactive acetylenic hydrogen that can be readily deprotonated, enabling participation in a broad range of carbon-carbon bond-forming reactions. This characteristic reactivity, combined with the moderate length of its carbon chain, offers a convenient balance between volatility and handling ease, making it a dependable reagent for method development and repeated experimental trials.

In Indonesian research and teaching laboratories, 1-Pentyne is commonly used as a model substrate in organic chemistry courses and in academic projects exploring alkyne chemistry. Researchers apply it to demonstrate fundamental transformations such as metal-catalyzed cross-coupling and selective hydrogenation, and to prepare intermediates for the further synthesis of higher-value compounds. Supplied through local laboratory distributors such as AMI Scientific, the compound is readily accessible for students and researchers alike, supporting reproducible experimental design and consistent results in both routine coursework and advanced synthetic studies.

• Metal-catalyzed cross-coupling reactions: the terminal alkyne participates readily in palladium- and copper-mediated couplings, making it a convenient substrate for building substituted alkynes and conjugated molecular systems.
• Selective hydrogenation studies: the triple bond can be reduced stepwise toward alkenes or alkanes, allowing researchers to investigate catalyst selectivity and reaction conditions in a controlled manner.
• Hydroboration and functionalization: reaction with borane reagents converts the terminal alkyne into vinyl boronate derivatives, which serve as versatile intermediates for further carbon-carbon bond formation.
• Nucleophilic addition at the triple bond: the electron-rich acetylenic center undergoes addition of nucleophiles, enabling the preparation of substituted alkenes and functionalized building blocks for downstream synthesis.
• Model substrate for mechanism studies: as a simple five-carbon alkyne, it provides a clear and easily analyzed system for probing reaction pathways, kinetics, and selectivity in organic chemistry coursework and research.

• Product code: P0068

1-Pentyne should be stored in a cool, well-ventilated area, away from direct sunlight, heat sources, and open flames, since the compound is highly flammable and volatile. Keep containers tightly closed and properly sealed when not in use to minimize evaporation and the accumulation of vapors. Use containers made of compatible materials, such as glass with appropriate closures, and store the chemical in a dedicated flammable-solvent cabinet. During handling, work inside a fume hood, wear suitable protective gloves, safety goggles, and flame-resistant laboratory apparel, and avoid sources of ignition such as sparks and static discharge. Keep only minimal quantities in the work area and ensure that appropriate fire-extinguishing equipment is available nearby before beginning any procedure.

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