1-Piperonylpiperazine (TCI P1041) is a heterocyclic compound in which a piperazine ring is attached to a piperonyl group. The piperonyl group is a benzyl unit that carries a 1,3-benzodioxole (methylenedioxy) ring. In the laboratory, the compound is used as a building block in medicinal chemistry and organic synthesis. One of its piperazine nitrogens is still free, so chemists can easily modify it further. The piperonylpiperazine motif appears in several pharmacologically relevant compounds, including drugs in the dopamine agonist class.
Researchers choose this compound because it gives them two important structural fragments in one reagent. The benzodioxole ring often appears in natural products and bioactive molecules. Piperazine is one of the most widely used scaffolds in drug design because it affects solubility and pharmacokinetic properties. The free secondary nitrogen can react through alkylation, acylation, Buchwald–Hartwig arylation, nucleophilic aromatic substitution, or reductive amination. This lets researchers build target molecules in only a few synthetic steps instead of putting both fragments together separately.
In Indonesia, this product suits pharmaceutical chemistry and organic synthesis laboratories that develop derivatives of bioactive compounds. University research groups working on structure–activity relationship studies can use it as a ready starting point for small compound libraries. Graduate students preparing piperazine-based analogues for theses can use it too. Industrial R&D teams exploring new heterocyclic candidates also benefit from a reliable reagent with a well-defined structure, supplied under the TCI brand.
- Medicinal chemistry building block: the free piperazine nitrogen lets researchers attach the piperonylpiperazine fragment to many different scaffolds when designing new drug candidates.
- N-alkylation and N-acylation reactions: the secondary amine reacts readily with alkyl halides and acylating agents, so chemists can prepare substituted piperazine derivatives in few steps.
- Buchwald–Hartwig and SNAr arylation: the nucleophilic nitrogen couples with aryl and heteroaryl partners, which makes it practical for preparing N-aryl piperazine structures found in pharmacologically relevant compounds.
- Reductive amination: the free amine condenses with aldehydes or ketones and is then reduced, giving researchers a mild and flexible way to extend the molecular framework.
- Structure–activity relationship studies: because it delivers both a benzodioxole ring and a piperazine scaffold, it is useful for building analogue series and comparing their biological activity.
| Brand | TCI (product code P1041) |
|---|---|
| CAS number | 32231-06-4 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | available in the pack sizes TCI offers for this item; please confirm the current option when you order |
| Physical form | refer to the TCI specification sheet supplied with the product |
| Storage | keep the container tightly closed and follow the storage conditions on the TCI label and Safety Data Sheet |
Store 1-Piperonylpiperazine in its original, tightly sealed container. Keep it in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials such as strong oxidizing agents and strong acids. Always follow the storage conditions given on the TCI label and Safety Data Sheet. Only trained personnel should handle the compound. They should wear suitable personal protective equipment, including safety glasses, chemical-resistant gloves, and a laboratory coat, and should work in a fume hood whenever possible. Avoid inhaling dust or vapour, and avoid contact with skin and eyes. Close the container right after use to protect the reagent from moisture and air. Dispose of residues and contaminated materials according to local regulations and your institution's chemical waste procedures.
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