Tetrabutylammonium Hydroxide (10% in Methanol) [for non-aqueous titration] TCI T0041

Chemical Identity

CAS No.: 2052-49-5
PubChem: CID 2723671·SID 87576061
Formula: C16H37NO
Molecular weight: 259.47 g/mol
Reference databases: ChemSpider·ECHA·Wikipedia

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: tetrabutylazanium hydroxide
SMILES: CCCC[N+](CCCC)(CCCC)CCCC.[OH-]
InChIKey: VDZOOKBUILJEDG-UHFFFAOYSA-M

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Volume 25mL 500mL

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Dokumen Keamanan & Mutu

↓ Unduh SDS / MSDS (PDF resmi TCI)

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TCI T0041 Tetrabutylammonium Hydroxide (10% in Methanol) is a strong organic base solution prepared specifically for non-aqueous titration. Tetrabutylammonium hydroxide (CAS 2052-49-5) is a quaternary ammonium base. In organic solvents it acts as a strong base, so it can titrate weakly acidic compounds that do not give a clear endpoint when titrated in water. Analytical laboratories use this solution as a standard titrant to determine the content of acidic active substances, for example when testing pharmaceutical raw materials and organic compounds. It is a dependable reagent wherever water-based acid-base methods fall short.

The main reason analysts choose this reagent is the large tetrabutylammonium cation, which keeps the salts formed during titration dissolved in the organic medium. This gives clean titration curves and sharp endpoints, whether detected with a visual indicator or by potentiometry. The methanol solvent mixes well with many common titration solvents, so the solution fits easily into existing analytical methods. Because the concentration is already fixed, the solution saves preparation time and reduces batch-to-batch variation compared with titrants made in-house. As with other basic titrants, it needs regular standardisation, because strong bases tend to absorb carbon dioxide from the air, which can change their strength.

In Indonesian laboratories, this solution is mainly used in quality control and analytical work that relies on non-aqueous titration. Typical users include pharmaceutical raw material testing labs, research institutions that study organic compounds, and university analytical chemistry laboratories that teach and apply non-aqueous methods. Laboratories value a ready-to-use titrant from an established brand such as TCI because it supports consistent results across routine analyses. Supplied through AMI Scientific, it is a practical choice for labs that run acidity assays on substances that cannot be titrated reliably in water.

TCI brochures (PDF)

Quaternary Ammonium Salts 2025-11-10 · p. 2

Related TCI products

Non-aqueous acid-base titration: This strong organic base works in organic media, so weakly acidic compounds that give unclear endpoints in water produce sharp, readable endpoints.
Assay of pharmaceutical raw materials: Laboratories use it as a standard titrant to determine the content of acidic active substances, which makes it suitable for routine quality testing of pharmaceutical ingredients.
Analysis of acidic organic compounds: The tetrabutylammonium salts formed stay dissolved in the organic medium, giving clean titration curves when assaying weakly acidic organic substances.
Potentiometric titration: Its sharp endpoints suit electrode-based endpoint detection, and the methanol solvent mixes well with many common titration solvents used in potentiometric methods.
Indicator-based titration and teaching: The fixed concentration saves preparation time and reduces batch-to-batch variation, which helps routine laboratories and academic training labs get consistent visual-endpoint results.

From the TCI brochure

Non-aqueous titration

Brand	TCI (product code T0041)
CAS number	2052-49-5
Molecular formula	—
Purity	—
Category	Chemistry > Synthetic Reagents > Acids, Bases [Synthetic Reagents]
Pack sizes	Available in the pack sizes listed for this product on this page
Physical form	Solution, 10% tetrabutylammonium hydroxide in methanol, for non-aqueous titration
Storage	Keep tightly closed to limit carbon dioxide uptake; follow the storage conditions on the TCI label and SDS

Store the solution in its original, tightly sealed container in a cool, dry, well-ventilated area away from heat, ignition sources, and acids. Keep the container closed whenever you are not drawing from it, because strong bases absorb carbon dioxide from the air, which can change the solution's strength. Standardise the titrant regularly to confirm its concentration before analytical use. The solution contains methanol and a strong base, so handle it in a fume hood and wear chemical-resistant gloves, safety goggles, and a laboratory coat. Avoid contact with skin and eyes, and do not inhale the vapours. Always consult the product label and the Safety Data Sheet for specific storage and handling instructions.

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