1,1,3,3-Tetraethoxypropane TCI T0093

Chemical Identity

CAS No.: 122-31-6
PubChem: CID 67147·SID 87576105
Formula: C11H24O4
Molecular weight: 220.31 g/mol
Purity: >95.0%(GC)
Reference databases: ChemSpider·ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1,1,3,3-tetraethoxypropane
SMILES: CCOC(CC(OCC)OCC)OCC
InChIKey: KVJHGPAAOUGYJX-UHFFFAOYSA-N

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1,1,3,3-Tetraethoxypropane from TCI (product code T0093, CAS 122-31-6) is an acetal compound that is chemically a protected form of malonaldehyde. Malonaldehyde is a simple dialdehyde that is unstable when stored in its free form. This compound locks both aldehyde groups as ethyl acetals, which makes it much easier to store and handle. When it is hydrolysed under acidic conditions, it releases malonaldehyde in a controlled way. In the laboratory, it therefore serves both as a malonaldehyde source for synthesis and as a starting material for analytical standards.

Researchers choose this material because it stays stable under neutral conditions but is easy to activate with acid. This gives them full control over when malonaldehyde forms and how much is produced. That control matters most in lipid oxidation analysis. Malonaldehyde is a key marker of lipid peroxidation, and standards prepared from tetraethoxypropane allow reproducible calibration curves. In organic synthesis, its three-carbon backbone has an electrophilic site at each end. This makes it an important precursor for building heterocyclic rings such as pyrimidines and pyrazoles.

In Indonesian laboratories, 1,1,3,3-Tetraethoxypropane is commonly found in research groups that study lipid oxidation and oxidative stress. Analysts use it to prepare malonaldehyde calibration standards for routine oxidation measurements. Synthetic chemistry groups also use it as a building block for heterocyclic compounds. Because it has a well-defined identity and a recognised brand, it suits both teaching laboratories and research facilities that need consistent results across many experiments over time.

Related TCI products

Malonaldehyde standard preparation: controlled acid hydrolysis releases a known amount of malonaldehyde, which makes it the usual precursor for reliable calibration standards.
Lipid peroxidation analysis: malonaldehyde is a key marker of lipid oxidation, so standards made from this compound allow reproducible calibration curves for oxidation assays.
Pyrimidine synthesis: its three-carbon backbone with two electrophilic ends reacts with suitable nitrogen nucleophiles, so it is a valuable precursor for building pyrimidine ring systems.
Pyrazole synthesis: the protected 1,3-dialdehyde equivalent condenses readily after acid activation, giving chemists a convenient route to pyrazole rings and related heterocycles.
Controlled malonaldehyde generation in synthesis: it stays stable under neutral conditions and activates with acid, so researchers decide exactly when and how much reactive dialdehyde forms.

Brand	TCI (product code T0093)
CAS number	122-31-6
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	available in the pack sizes TCI supplies; see the product listing for the current options
Physical form	liquid acetal compound
Storage	keep the container tightly closed, away from acids and moisture

Store 1,1,3,3-Tetraethoxypropane in its original, tightly sealed container in a cool, dry, well-ventilated area, away from heat and ignition sources. The compound hydrolyses under acidic conditions, so keep it away from acids and moisture to keep it stable until use. Use clean glass or chemically compatible containers for any portions you transfer. Wear appropriate personal protective equipment, including gloves, safety glasses and a lab coat. Handle the material in a fume hood or a well-ventilated area. Always check the TCI Safety Data Sheet for specific hazard and disposal information before use.

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