4-(Trifluoromethyl)benzoic Acid TCI T1145

Chemical Identity

CAS No.: 455-24-3
PubChem: CID 9966·SID 87576933
Formula: C8H5F3O2
Molecular weight: 190.12 g/mol
Purity: >98.0%(T)
Reference databases: ChEBI·ChemSpider·ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 4-(trifluoromethyl)benzoic acid
SMILES: C1=CC(=CC=C1C(=O)O)C(F)(F)F
InChIKey: SWKPKONEIZGROQ-UHFFFAOYSA-N

Rp 557.550,00

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Berat 5g 25g

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4-(Trifluoromethyl)benzoic Acid is a benzoic acid that carries a trifluoromethyl group at the para position of the benzene ring. It belongs to the family of fluorinated building blocks and is widely used in organic synthesis, particularly in medicinal chemistry and agrochemical research. This TCI T1145 product combines a carboxylic acid group, which is easily converted into esters, amides, or acyl chlorides, with a CF3 group that gives its derivatives distinctive characteristics. In the laboratory it serves as a starting material for introducing an aromatic trifluoromethyl unit into larger target molecules.

The trifluoromethyl group is known as a strongly electron-withdrawing substituent that is also fairly lipophilic and relatively stable chemically. In molecular design, it is often used to influence the acidity, lipophilicity, and metabolic resistance of a compound. Because the para position preserves the symmetry of the ring, this material is convenient to use in coupling reactions and amide formation, and the resulting products are generally straightforward to analyze. Researchers also use it as a fluorinated aromatic carboxylic acid for spectroscopic comparison, including fluorine-19 NMR.

In Indonesian laboratories, this material suits research groups working in organic synthesis, pharmaceutical science, and materials chemistry that want to incorporate an aromatic CF3 group into their target molecules. It is a practical choice for teams that need a dependable fluorinated building block from an established brand. It is available in 5 g and 25 g pack sizes, so laboratories can choose a quantity that matches the scale of their work, from initial route scouting to repeated synthesis.

TCI brochures (PDF)

Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 40

Related TCI products

Organic synthesis of trifluoromethylated compounds: the carboxylic acid group reacts readily to form esters, amides, or acyl chlorides, which makes this material a convenient way to introduce an aromatic CF3 unit into target molecules.
Medicinal chemistry research: the CF3 group is often used to influence acidity, lipophilicity, and metabolic resistance, so this building block suits teams designing and comparing candidate molecules in drug discovery programs.
Agrochemical research: as a fluorinated building block frequently used in this field, it supports the preparation of new candidate structures that carry an aromatic trifluoromethyl group for further evaluation.
Coupling and amide formation reactions: the para substitution keeps the ring symmetrical, so the acid performs well in coupling reactions and gives products that are generally easy to analyze and characterize.
Spectroscopic reference work: as a fluorinated aromatic carboxylic acid, it can serve as a comparison compound in analytical studies, including fluorine-19 NMR, where a clear fluorine signal is useful.

Brand	TCI
CAS number	455-24-3
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes	5 g and 25 g
Physical form	—
Storage	keep tightly closed in a cool, dry place, and follow the supplier's label and safety data sheet

Product code: T1145

Store 4-(Trifluoromethyl)benzoic Acid in its original, tightly closed container in a cool, dry, well-ventilated area, away from moisture, heat, and incompatible materials such as strong bases and strong oxidizing agents. Always confirm the exact storage conditions on the label and in the supplier's safety data sheet. Use clean, dry spatulas and glassware when weighing, and reseal the bottle promptly after use. As with any laboratory chemical, wear safety glasses, gloves, and a laboratory coat, and work in a fume hood or well-ventilated space to avoid inhaling dust. Wash hands after handling, and dispose of waste according to your institution's chemical waste procedures.

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