Collection: Guanidinylation [Synthetic Reagents]

Guanidinylation [Synthetic Reagents] — contains synthetic reagents protected with Boc groups or thiourea, used to introduce guanidine groups into a molecule through guanidinylation reactions. This class of reagents is an important tool for forming non-halogen C–N bonds in organic synthesis and peptide chemistry.

Guanidinylation reagents such as 1,3-bis(tert-butoxycarbonyl)thiourea and N-(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine are used by synthetic chemists to convert primary amines into protected guanidine groups in the synthesis of arginine analogs, agmatine, or other bioactive guanidine-derived compounds. Derivatives such as 1,2,4-triazole-1-carboximidamide hydrochloride are also popular as guanidine transfer reagents in peptide synthesis and medicinal chemistry, especially in forming strongly basic functional groups at the final stage of a synthetic route.

Example products in this collection: TCI T3124 19503-26-5 1,2,4-Triazole-1-carboximidamide Hydrochloride, TCI C2709 152120-62-2 N-(Carbobenzoxy)-1H-pyrazole-1-carboxamidine, TCI T2964 216584-22-4 1,2,3-Tris(tert-butoxycarbonyl)guanidine, TCI M3651 34840-23-8 1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudourea, TCI B4559 145013-05-4 1,3-Bis(tert-butoxycarbonyl)thiourea, TCI S0838 1934-75-4 Sodium Dicyanamide, TCI B4535 107819-90-9 N,N'-Bis(tert-butoxycarbonyl)-S-methylisothiourea, TCI A2055 4023-02-3 1-Amidinopyrazole Hydrochloride.

Pay attention to the number and type of protecting groups (mono-, bis-, or tris-Boc), as they affect reaction selectivity, as well as the conditions for removing the protecting groups and the purity of the reagent after the guanidinylation step is complete. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under C-X(Non-Halogen) Bond Formation [Synthetic Reagents], often used together in a single laboratory workflow:

• C-H Bond Activation Reaction [Synthetic Reagents]
• Formylation [Synthetic Reagents]
• Phosphorylation [Synthetic Reagents]
• Mitsunobu Reaction [Synthetic Reagents]
• Vinylation [Synthetic Reagents]
• Amination [Synthetic Reagents]

Back to C-X(Non-Halogen) Bond Formation [Synthetic Reagents]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official distributor of TCI Japan in Indonesia — to check availability and lead time directly with Japan.