Collection: N-Terminal Cysteine Residue-specific Conjugation Reagents
N-Terminal Cysteine Residue-specific Conjugation Reagents — includes reagents based on the 2-cyanopyridine oxime (CPO) group and activated PEG linkers such as azide, DBCO, alkyne, or biotin, designed to react selectively with the cysteine residue at the N-terminus of proteins and peptides. These reagents enable directed covalent bond formation without disturbing other internal cysteine residues.
N-Terminal Cysteine Residue-specific Conjugation Reagents are used in bioconjugation to label proteins or antibodies site-specifically, for example by attaching biotin for detection, DBCO for copper-free click reactions, or azide as a partner for further reactions. This approach is popular in antibody-drug conjugate development research and protein tracking because the conjugation results are more uniform than random lysine labeling.
Product examples in this collection: TCI A3687 1807540-88-0 N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]-4-formylbenzamide, TCI C3902 2499715-43-2 CPO-PFP, TCI C3948 CPO-PEG3-azide (ca. 0.2 mol/L in Dimethyl Sulfoxide), TCI C3903 CPO-PEG3-Biotin, TCI C3916 CPO-PEG3-DBCO (contains 5% Acetonitrile at maximum), TCI C3904 CPO-PEG3-Alkyne.
Check the carrier solvent (for example, solutions in Dimethyl Sulfoxide or residual acetonitrile content) and the reagent's terminal functional groups to suit the next step in a stepwise bioconjugation workflow. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.
Other categories parallel under Bioconjugation, often used together in one laboratory workflow:
- PEGylation Reagents and PEG Spacers
- Biotins and Streptavidins
- Copper-free Click Reaction Reagents
- Functionality Creating Reagents
- Zero-length Crosslinkers
- Functional Group Blocking Reagents
Back to Bioconjugation. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — for availability checks and direct lead times from Japan.