Collection: PEGylation Reagents and PEG Spacers

PEGylation Reagents and PEG Spacers — gathers discrete, monodisperse polyethylene glycol (PEG) chains with reactive groups at one or both ends of the molecule, such as amine, Boc group, carboxylic acid, alkyne, or maleimide, functioning as hydrophilic spacers (linkers) that connect two fragments within a conjugate.

This type of PEG spacer is widely used in bioconjugation to link biomolecules such as peptides, antibodies, or nanoparticles with dyes, targeting ligands, or solid surfaces, while maintaining water solubility and reducing non-specific interactions. The reactive groups at the chain ends (free amine, alkyne for click reactions, or maleimide for thiols) enable sequential two-step linking, so bioorganic chemists can design conjugates with controlled spacing and orientation.

Example products in this collection: TCI T3198 68960-97-4 1,14-Diamino-3,6,9,12-tetraoxatetradecane, TCI B5587 186020-66-6 tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, TCI T3114 208827-90-1 Triethylene Glycol Mono(2-propynyl) Ether, TCI B5651 882847-13-4 21-[(tert-Butoxycarbonyl)amino]-4,7,10,13,16,19-hexaoxaheneicosanoic Acid, TCI T2634 110429-45-3 Triethylene Glycol 2-Bromoethyl Methyl Ether, TCI B5665 756525-91-4 (Boc-amino)-PEG4-carboxylic Acid, TCI B5141 153086-78-3 N-(tert-Butoxycarbonyl)-2,2'-(ethylenedioxy)diethylamine, TCI B5667 115597-84-7 1,8-Bis(maleimido)-3,6-dioxaoctane.

Pay attention to the PEG chain length (number of ethylene oxide units), the type and reactivity of the end groups, whether protecting groups such as Boc need to be removed first, as well as purity and physical form (viscous liquid or solid) before use in conjugate synthesis. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other related categories under Bioconjugation, often used together in a single laboratory workflow:

• Biotins and Streptavidins
• Copper-free Click Reaction Reagents
• Functionality Creating Reagents
• Zero-length Crosslinkers
• Functional Group Blocking Reagents
• N-Terminal Cysteine Residue-specific Conjugation Reagents

Back to Bioconjugation. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.