Collection: Weinreb Amides [C-C Bond Formation]

Weinreb Amides [C-C Bond Formation] — contains N-methoxy-N-methyl amide (Weinreb amide) compounds of various acyl groups, from fluorinated acetyl to aromatic and heterocyclic derivatives, which function as protected intermediates for controlled ketone synthesis.

Weinreb amides are used by synthetic organic chemists as key intermediates in reactions with organometallic reagents such as Grignard or organolithium to produce ketones without the risk of double addition, because the cyclic chelate complex formed stabilizes the tetrahedral intermediate. These compounds are commonly used at the carbon-carbon bond formation stage in total synthesis of natural products and development of pharmaceutical molecules.

Example products in this collection: TCI T3326 104863-67-4 2,2,2-Trifluoro-N-methoxy-N-methylacetamide, TCI B5728 192436-83-2 4-Bromo-N-methoxy-N-methylbenzamide, TCI B3708 139290-70-3 tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate, TCI B6019 87694-49-3 N-(tert-Butoxycarbonyl)-L-alanine N'-Methoxy-N'-methylamide, TCI M3099 95091-91-1 N-Methoxy-N-methylnicotinamide, TCI C2272 67442-07-3 2-Chloro-N-methoxy-N-methylacetamide, TCI M3098 122334-36-5 N-Methoxy-N,4-dimethylbenzamide, TCI C3486 122334-37-6 4-Chloro-N-methoxy-N-methylbenzamide.

Pay attention to the acyl group and aromatic substituents on the amide structure because they determine the final ketone product, as well as the purity level, which affects the consistency of organometallic reaction results. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under C-C Bond Formation [Synthetic Reagents], often used together in a single laboratory workflow:

• Cross-coupling Reaction using Transition Metal Catalysts [C-C Bond Formation]
• Olefination [C-C Bond Formation]
• C-C Bond Formation (Other) [Synthetic Reagents]
• Carbon Monoxide Surrogate Reagents [C-C Bond Formation]

Back to C-C Bond Formation [Synthetic Reagents]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official distributor of TCI Japan in Indonesia — for availability checks and direct lead time from Japan.