1-(tert-Butyldimethylsilyl)imidazole [tert-Butyldimethylsilylating Agent] TCI B1043

Chemical Identity

CAS No.: 54925-64-3
PubChem: CID 171385·SID 87563992
Formula: C9H18N2Si
Molecular weight: 182.34 g/mol
Purity: >98.0%(T)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: tert-butyl-imidazol-1-yl-dimethylsilane
SMILES: CC(C)(C)[Si](C)(C)N1C=CN=C1
InChIKey: VUENSYJCBOSTCS-UHFFFAOYSA-N

Rp 2.491.650,00

~~Rp 1.757.700,00~~ Rp 2.491.650,00

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1-(tert-Butyldimethylsilyl)imidazole is a chemical compound widely used as a silylating agent in organic chemistry reactions. It plays a crucial role in laboratories by facilitating substitution and coupling reactions, particularly in the synthesis of complex heterocyclic compounds. This reagent is highly valued for its ability to activate imidazole rings, enabling high reactivity in various chemical processes. Its controlled reactivity and stability make it an essential component in synthetic chemistry workflows.

The compound’s chemical properties, including its stability and controlled reactivity, make it a preferred choice for laboratory applications. It exhibits a high degree of specificity in interacting with different substrates, allowing for precise chemical transformations. Its molecular structure supports efficient participation in synthetic pathways, making it ideal for use in advanced organic synthesis. These characteristics ensure that it remains a reliable and effective reagent in both academic and industrial research settings.

In Indonesian laboratories, 1-(tert-Butyldimethylsilyl)imidazole is commonly used in organic chemistry research, especially in higher education institutions and research organizations. It is a key reagent in the synthesis of heterocyclic compounds, which have broad applications in pharmaceutical and materials science. Its reliability and performance make it a staple in chemical synthesis projects conducted in Indonesia.

Advantages (TCI brochure)

DMAS ethers generally more stable than TMS ethers and give better GC separation

TCI brochures (PDF)

GC Derivatization Reagents 2026-03-25 · p. 3
Protecting Agents 2025-03-25 · p. 5
Please inquire for pricing and availability of listed products to our local sales representatives. Si Si Et 2026-07-16 · p. 10

Related TCI products

Organic synthesis of heterocyclic compounds due to its ability to activate imidazole rings and facilitate coupling reactions.
Development of pharmaceutical intermediates where controlled reactivity and specificity are essential for synthetic pathways.
Research in materials science for the creation of complex molecular structures with tailored properties.
Academic teaching and experimental work in chemistry laboratories requiring precise and reliable reagents.
Industrial chemical processes involving the synthesis of high-purity compounds with specific functional groups.

From the TCI brochure

Structural analysis of hydroxysteroids by GC-MS
Trace analysis of prostaglandins and bile acids

Brand	TCI
CAS number	54925-64-3
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes	Available in various quantities as per standard laboratory supply formats
Physical form	Solid or liquid, depending on the specific formulation
Storage	Store in a cool, dry place away from moisture and direct sunlight

This compound should be stored in a cool, dry environment to maintain its chemical stability and reactivity. It is recommended to use airtight containers to prevent exposure to moisture and air, which could affect its performance. Due to its chemical nature, it should be handled in a well-ventilated area, and appropriate personal protective equipment should be worn. Avoid contact with incompatible materials, and ensure that storage conditions are consistent with standard laboratory safety protocols. Regular inspection of storage containers is advised to ensure long-term usability and safety.

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