1-(Dimethylethylsilyl)imidazole is a chemical compound widely used as a silylating agent in various organic chemical reactions. It plays a crucial role in the synthesis of heterocyclic compounds, particularly in the formation of silicon bonds within complex molecular structures. In laboratory settings, this compound functions as a reagent that facilitates molecular structure modification, especially in substitution and silylation reactions. Its reactivity makes it an essential tool in organic chemistry research and the synthesis of pharmacological compounds.
This compound is valued for its high efficiency in forming silicon bonds and its ability to produce high-purity products. Its chemical stability under specific conditions, combined with its reactivity towards water and oxidizers, makes it a versatile reagent. The compound's effectiveness in silylation reactions, where it acts as a key intermediate, ensures its reliability in both academic and industrial research. Its chemical properties make it a preferred choice for applications requiring precision and accuracy.
In Indonesian laboratories, 1-(Dimethylethylsilyl)imidazole is commonly used in organic chemistry research, particularly in pharmaceutical and material science fields. Its role in the synthesis of heterocyclic compounds makes it relevant for studies involving drug development and advanced material synthesis. The compound is essential for researchers aiming to achieve high-quality results in complex chemical processes.
Advantages (TCI brochure)
- DMAS ethers generally more stable than TMS ethers and give better GC separation
- Distinguishes alcoholic and phenolic hydroxy groups by GC-MS through sandwich injection
TCI brochures (PDF)
- GC Derivatization Reagents 2026-03-25 · p. 3
- Please inquire for pricing and availability of listed products to our local sales representatives. Si Si Et 2026-07-16 · p. 10
Related TCI products
- TCI B1043 54925-64-3 1-(tert-Butyldimethylsilyl)imidazole [tert-Butyldimethylsilylating Agent]
- TCI D1596 81452-04-2 1-(Dimethylisopropylsilyl)imidazole [Dimethylisopropylsilylating Agent]
- TCI H0467 32477-35-3 1-(Heptafluorobutyryl)imidazole [Acylating Agent]
- TCI T0585 18156-74-6 N-Trimethylsilylimidazole [Trimethylsilylating Reagent]
- TCI T0473 503-30-0 Trimethylene Oxide
- TCI T0670 1546-79-8 1-(Trifluoroacetyl)imidazole
- Organic synthesis of heterocyclic compounds due to its efficient silylating properties and ability to form stable silicon bonds.
- Pharmaceutical research for the development of new drugs, as it aids in the modification of molecular structures with high precision.
- Material science applications where silicon-based bonds are required for the creation of advanced polymers and composites.
- Chemical modification of complex molecules through substitution reactions, leveraging its reactivity and selectivity.
- Research in synthetic chemistry requiring high-purity products, as it consistently delivers reliable and reproducible results.
From the TCI brochure
- Structural analysis of hydroxysteroids by GC-MS
- Trace analysis of prostaglandins and bile acids
| Brand | TCI |
|---|---|
| CAS number | 62365-34-8 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | Available in various quantities as per standard laboratory requirements |
| Physical form | Liquid |
| Storage | Store in a cool, dry place away from moisture and oxidizing agents |
Data from the TCI brochure
| Sandwich injection sequence | 0.2 µL DMESI, 0.1 µL reaction mixture, 0.2 µL DMESI (beta-estradiol bis-TMS ether prepared in SIM (0.1 mg in 20 µL, 30 min at room temperature)) |
|---|---|
| GC condition (Figures 1-2) | Column 007-1 25 m x 0.53 mm I.D. x 1 µm; 250 °C; FID; splitless injection; He 0.3 kg/cm2, 30 cm/s (inj. 300 °C) |
Source: TCI brochure A1104 (2026-03-25)
This compound should be stored in a cool, dry environment, away from moisture and oxidizing agents to maintain its chemical stability. It is recommended to use airtight containers made of glass or polyethylene to prevent exposure to air and humidity. Due to its reactivity towards water and oxidizers, it should be handled with care in a well-ventilated laboratory setting. Protective gloves and safety goggles should be worn during handling to ensure personal safety. Avoid contact with skin and eyes, and ensure proper disposal of any unused material in accordance with local regulations.
—
![1-(Dimethylethylsilyl)imidazole [Dimethylethylsilylating Agent] (CAS 62365-34-8) - TCI D1516 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510D1516.jpg?v=1767103171&width=1445)