TCI C0470 Cyclohexanecarboxylic Acid (CAS 98-89-5) is an alicyclic carboxylic acid that serves as a versatile non-heterocyclic building block. Its carboxyl group readily undergoes esterification, amidation, reduction, and activation to acyl derivatives, while the cyclohexane ring introduces a saturated three-dimensional motif into target molecules. This makes it particularly useful in medicinal chemistry programmes that replace flat aromatic rings with saturated scaffolds. Supplied in 25 g and 500 g packs, it should be stored in a cool, dry place in a tightly closed container, away from strong bases and oxidising agents.
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- Liu et al. (1994). Pharmacokinetics and Pharmacodynamics of Valproate Analogues in Rats. IV. Anticonvulsant Action and Neurotoxocity of Octanoic Acid, Cyclohexanecarboxylic Acid, and 1‐Methyl‐1 ‐Cyclohexanecarboxylic Acid. Epilepsia doi:10.1111/j.1528-1157.1994.tb02939.x
- Liu et al. (1992). Pharmacokinetics and pharmacodynamics of valproate analogs in rats. III. Pharmacokinetics of valproic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid in the bile-exteriorized rat.. Drug Metabolism and Disposition doi:10.1016/s0090-9556(25)08799-9
- Liu et al. (1993). Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1‐methyl‐1‐cyclohexanecarboxylic acid. Biopharmaceutics & Drug Disposition doi:10.1002/bdd.2510140406
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