TCI C0621 2'-Chloroacetanilide is an acetanilide derivative carrying a chlorine atom at the ortho position of the aromatic ring. Its amide group is a well-known directing group in C–H activation chemistry, while the aryl chloride offers a handle for cross-coupling reactions. These features make it a convenient model substrate for methodology development and heterocycle synthesis. Supplied as a 25 g solid, it should be handled with gloves and eye protection and stored cool, dry, and tightly closed.
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- Griffith et al. (2018). Metabolic Profiling of Chloroacetanilide Herbicides in Earthworm Coelomic Fluid Using 1H NMR and GC–MS. Journal of Proteome Research doi:10.1021/acs.jproteome.8b00081
- Konopka (1994). Anaerobic degradation of chloroacetanilide herbicides. Applied Microbiology and Biotechnology doi:10.1007/bf00902754
- Rowe et al. (1990). Factors Affecting Chloroacetanilide Injury to Corn (Zea mays). Weed Technology doi:10.1017/s0890037x00026634
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