TCI C0635 N-Benzyloxycarbonyl-L-serine (CAS 1145-80-8) is Z-protected L-serine, supplied with the side-chain hydroxyl group left free. That free hydroxyl makes it valuable both for building serine-containing peptides and for studying side-chain modifications such as etherification or phosphorylation. The benzyloxycarbonyl group remains stable during coupling and is removed selectively by hydrogenolysis when required. AMI Scientific offers this TCI reagent in a 5 g pack for research-scale peptide synthesis and derivative preparation.
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- Sypniewski et al. (2000). (R)-tert-Butoxycarbonylamino-fluorenylmethoxycarbonyl-glycine from (S)-Benzyloxycarbonyl-serine or from Papain Resolution of the Corresponding Amide or Methyl Ester. The Journal of Organic Chemistry doi:10.1021/jo000736e
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