TCI C0770 Cyclobutanol (CAS 2919-23-5) is a strained four-membered cyclic alcohol widely used as a compact synthetic building block. Its ring strain enables ring-opening and rearrangement chemistry, including alkoxy radical processes that are not accessible with larger cycloalkanols. The hydroxyl group is readily oxidised to cyclobutanone or converted into esters, ethers, and leaving groups. AMI Scientific offers this TCI product in 1 g and 5 g pack sizes, which suit research-scale synthesis of this volatile liquid.
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- Ren et al. (2016). C−C Bond‐Forming Strategy by Manganese‐Catalyzed Oxidative Ring‐Opening Cyanation and Ethynylation of Cyclobutanol Derivatives. Angewandte Chemie doi:10.1002/ange.201510973
- (2010). Rhodium Catalysts Cleave Cyclobutanol to Asymmetric Methyl Quaternary Centers. Synfacts doi:10.1055/s-0029-1220112
- NEMOTO et al. (1996). ChemInform Abstract: Vinyl Cyclobutanol Strategy for Halogenated Cyclopentanoids.. ChemInform doi:10.1002/chin.199612092
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