TCI
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Description
TCI C0991 Sodium Chlorodifluoroacetate (CAS 1895-39-2) is a solid fluorinated building block widely used as an in-situ difluorocarbene source. On heating it enables gem-difluorocyclopropanation of alkenes and difluoromethylation of nucleophiles such as phenols, thiols and amines. AMI Scientific offers this TCI product in 25 g, 100 g and 500 g pack sizes to suit exploratory through repeated synthetic work. Keep the container tightly closed, ensure adequate venting during heated reactions, and follow the manufacturer's label and safety data sheet.
Scientific References
- Mehta et al. (2014). ChemInform Abstract: S‐, N‐, and Se‐Difluoromethylation Using Sodium Chlorodifluoroacetate.. ChemInform doi:10.1002/chin.201410085
- Mehta et al. (2013). S-, N-, and Se-Difluoromethylation Using Sodium Chlorodifluoroacetate. Organic Letters doi:10.1021/ol402370f
- Williams et al. (2015). ChemInform Abstract: Mild Chlorodifluoroacylation of Indoles via Self‐Activation of Sodium Chlorodifluoroacetate.. ChemInform doi:10.1002/chin.201505133
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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