Methyl Chlorodifluoroacetate TCI C1586

Chemical Identity

Other names: Chlorodifluoroacetic Acid Methyl Ester
CAS No.: 1514-87-0
PubChem: CID 73935·SID 87566581
Formula: C3H3ClF2O2
Molecular weight: 144.50 g/mol
Purity: >97.0%(GC)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: methyl 2-chloro-2,2-difluoroacetate
SMILES: COC(=O)C(F)(F)Cl
InChIKey: AWUPLMYXZJKHEG-UHFFFAOYSA-N
MDL: MDL00000775

Rp 742.350,00

~~Rp 534.450,00~~ Rp 742.350,00

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Berat 5g 25g

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TCI C1586 Methyl Chlorodifluoroacetate (CAS 1514-87-0) is a widely used fluorinated building block and a practical precursor for generating difluorocarbene. It enables the introduction of difluoromethylene and difluoromethyl motifs into target molecules, supporting pharmaceutical, agrochemical, and functional materials research. Typical uses include difluoromethylation of phenols and thiols as well as the preparation of fluorinated cyclopropanes. AMI Scientific supplies this TCI reagent in 5 g and 25 g packages; please observe the handling precautions in the official TCI Safety Data Sheet.

TCI brochures (PDF)

Difluorocarbene Precursors 2015-02-19 · p. 1
Difluoromethylation Reagents, Difluoromethylenation Reagents 2026-05-18 · p. 2
Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 8

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From the TCI brochure

Difluorocarbene (:CF2) precursor for cyclopropanation of alkenes using HMPA-LiCl (Wheaton, Burton, J. Fluor. Chem. 1976)

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Data from the TCI brochure

Kemasan	5 g / 25 g

Source: TCI brochure RR029 (2015-02-19)

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SU et al. (1992). ChemInform Abstract: Methyl Chlorodifluoroacetate. A Convenient Trifluoromethylating Agent.. ChemInform doi:10.1002/chin.199231150
De-Bao et al. (1991). Methyl chlorodifluoroacetate a convenient trifluoromethylating agent. Tetrahedron Letters doi:10.1016/0040-4039(91)80566-o
Blanco et al. (2016). Atmospheric sink of methyl chlorodifluoroacetate and ethyl chlorodifluoroacetate: temperature dependent rate coefficients, product distribution of their reactions with Cl atoms and CF 2 ClC(O)OH formation. RSC Advances doi:10.1039/c6ra03454c

References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.

References cited in the TCI brochure

Gregory A. Wheaton. Methyl chlorodifluoroacetate as a precursor for the generation of difluorocarbene Journal of Fluorine Chemistry, 1976. doi:10.1016/s0022-1139(00)82904-8