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Description
TCI C1586 Methyl Chlorodifluoroacetate (CAS 1514-87-0) is a widely used fluorinated building block and a practical precursor for generating difluorocarbene. It enables the introduction of difluoromethylene and difluoromethyl motifs into target molecules, supporting pharmaceutical, agrochemical, and functional materials research. Typical uses include difluoromethylation of phenols and thiols as well as the preparation of fluorinated cyclopropanes. AMI Scientific supplies this TCI reagent in 5 g and 25 g packages; please observe the handling precautions in the official TCI Safety Data Sheet.
Scientific References
SU et al. (1992). ChemInform Abstract: Methyl Chlorodifluoroacetate. A Convenient Trifluoromethylating Agent.. ChemInformdoi:10.1002/chin.199231150
De-Bao et al. (1991). Methyl chlorodifluoroacetate a convenient trifluoromethylating agent. Tetrahedron Lettersdoi:10.1016/0040-4039(91)80566-o
Blanco et al. (2016). Atmospheric sink of methyl chlorodifluoroacetate and ethyl chlorodifluoroacetate: temperature dependent rate coefficients, product distribution of their reactions with Cl atoms and CF 2 ClC(O)OH formation. RSC Advancesdoi:10.1039/c6ra03454c
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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