TCI C1306 4-Chlorophenacyl Chloride is a highly electrophilic α-haloketone widely used in heterocyclic synthesis. It reacts with thioamides and thioureas in Hantzsch thiazole formation and also participates in imidazole and oxazole ring construction. In analytical work it serves as a derivatising reagent that converts carboxylic acids into UV-detectable phenacyl esters. AMI Scientific offers this TCI reagent in 5 g and 25 g pack sizes; because α-haloketones are strong lachrymators, all handling should take place in a fume hood.
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- Yu et al. (2015). Reduction of m-chlorophenacyl chloride coupled with regeneration of NADPH by recombinant Escherichia coli cells co-expressing both carbonyl reductase and glucose 1-dehydrogenase. Annals of Microbiology doi:10.1007/s13213-015-1114-1
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