TCI C1351 N-Benzyloxycarbonyl-L-threonine (CAS 19728-63-3), commonly known as Z-L-Thr-OH, is an amino-protected threonine derivative for peptide chemistry. The benzyloxycarbonyl group is removed under neutral hydrogenolysis conditions, making it fully orthogonal to acid- and base-labile protecting groups such as Boc and Fmoc. It is routinely used in solution-phase peptide synthesis, glycopeptide fragment preparation, and the construction of modified peptide analogues. AMI Scientific supplies this TCI reagent in a 10 g pack size for research laboratories.
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- Delacotte et al. (1992). Oxidation, With Chiral Retention, of Benzyloxycarbonyl Threonine Methyl Ester. Synthetic Communications doi:10.1080/00397919209409256
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