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Description
TCI C1545, (Chloromethylene)dimethyliminium Chloride (CAS 3724-43-4), is the isolated form of the Vilsmeier reagent, supplied as a ready-to-use solid rather than generated in situ. It acts as a powerful electrophilic and dehydrating agent, enabling Vilsmeier–Haack formylation of electron-rich aromatics, activation of carboxylic acids, dehydration of amides to nitriles, and conversion of alcohols to chlorides. Within glycoscience, its dehydrative activation chemistry is applied to carbohydrate donors and related transformations. Offered by AMI Scientific in 25 g and 250 g packs, this highly moisture-sensitive solid must be weighed under dry inert conditions and stored tightly closed.
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