TCI C1565 3-Chloro-2-chloromethyl-1-propene is a bifunctional building block bearing two reactive allylic chloromethyl groups flanking an exocyclic double bond. Its symmetry makes it a convenient reagent for double alkylation of stabilised nucleophiles, a route commonly used to assemble carbocyclic and spirocyclic frameworks. The remaining alkene offers a handle for downstream hydrogenation, oxidation, or metathesis chemistry. AMI Scientific supplies this TCI reagent in 5 g and 25 g pack sizes for both exploratory and multi-step synthetic work.
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- (2017). Selective N-Methylation of Pyrimidone with Chloro(chloromethyl)dimethylsilane–KF. Synfacts doi:10.1055/s-0036-1591613
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Produk Terkait
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