3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate TCI C1578

Chemical Identity

Other names: CHAPS
CAS No.: 75621-03-3
Formula: C32H58N2O7S
Molecular weight: 614.88 g/mol
Purity: >97.0%(N)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 3-[dimethyl-[3-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propyl]azaniumyl]propane-1-sulfonate
SMILES: CC(CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
InChIKey: UMCMPZBLKLEWAF-BCTGSCMUSA-N
MDL: MDL00012116
PubChem: CID 107670

Rp 955.500,00

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TCI C1578 CHAPS (CAS 75621-03-3) is a zwitterionic, bile-acid-derived surfactant widely used for the gentle solubilisation of hydrophobic components. Its steroid backbone paired with a dual-charged head group gives it strong solubilising power while remaining net-neutral in charge under common working conditions. Typical applications include membrane protein extraction, two-dimensional electrophoresis sample preparation, buffer formulation, and polymer interface studies. AMI Scientific offers this TCI reagent in convenient 1 g and 5 g packages; please refer to the official TCI documentation for full technical and safety information.

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Tornel et al. (1991). Inhibition of cholinesterases by the zwitterionic detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). Bioorganic Chemistry doi:10.1016/0045-2068(91)90038-q
Nomura (2001). Incomplete Dialysis of Protein Samples Containing 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate May Lead to Erroneous Estimation of Histidine Content on Amino Acid Analysis. Analytical Biochemistry doi:10.1006/abio.2000.4971
Shnigir et al. (2004). Transformation of Phospholipids by Cabbage Phospholipase D in Mixed Micelles Containing 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate. Applied Biochemistry and Microbiology doi:10.1023/b:abim.0000025942.11918.39

References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.