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CAS 81103-11-9

Clarithromycin TCI C2220

Clarithromycin TCI C2220
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Description

TCI C2220 Clarithromycin is a semi-synthetic macrolide antibiotic supplied by Tokyo Chemical Industry (TCI) as a research-grade raw material for microbiology, pharmaceutical, and biotechnology laboratories. The compound works by binding to the bacterial 50S ribosomal subunit, thereby inhibiting the process of protein synthesis, and for this reason it is widely used as a test agent in antimicrobial susceptibility studies as well as a comparator in analytical method development. On the laboratory bench, clarithromycin serves as a reference reagent that helps researchers understand macrolide behaviour, compare antibacterial potency between isolates, and build working protocols that stay consistent from one batch to the next.

The characteristic that makes clarithromycin such a frequent choice is its 14-membered macrolide ring bearing a methoxy group at position 6, which gives it better stability under acidic conditions than its predecessor, so that working solutions and test preparations are relatively more dependable. The compound is lipophilic and tends to be poorly soluble in water, but it can be dissolved in organic solvents such as methanol, ethanol, acetone, or DMSO, giving researchers flexibility in preparing stock solutions to suit the particular assay format and dilution scheme in use.

In Indonesian laboratories, this material is typically found in microbiology units running susceptibility testing, in pharmaceutical laboratories developing and validating analytical methods, and in biotechnology facilities studying macrolide activity. Because it functions as a reference reagent, it supports work where results must be comparable across runs and across operators, and it fits naturally into routine bench workflows that require a consistent, well-characterised macrolide standard for research purposes.

Laboratory Applications

  • Antimicrobial susceptibility testing — as a macrolide test agent, it allows researchers to compare antibacterial potency between bacterial isolates under controlled and repeatable laboratory conditions.
  • Analytical method development — serves as a comparator during the design of chromatographic and other analytical procedures, giving method developers a consistent macrolide reference to work against.
  • Protein synthesis inhibition studies — its binding to the bacterial 50S ribosomal subunit makes it a useful probe for research examining how macrolides interrupt bacterial protein synthesis.
  • Macrolide behaviour research — the well-defined 14-membered ring structure with a 6-position methoxy group makes it a suitable model compound for studying macrolide chemistry and stability.
  • Batch-to-batch protocol standardisation — as a reference reagent it helps laboratories build and maintain working protocols that remain consistent from one experimental batch to the next.

Specifications

  • Brand: TCI (Tokyo Chemical Industry)
  • CAS number: 81103-11-9
  • Product code: C2220
  • Category: Life Science > Biochemicals and Reagents > Antibiotics
  • Pack sizes: available in standard TCI research pack sizes; please confirm the required size when ordering
  • Storage: store according to the conditions stated on the manufacturer's label and safety data sheet

Handling and Storage

Store clarithromycin in a tightly closed original container, kept dry and protected from light, and follow the storage conditions specified on the manufacturer's label and safety data sheet. Because the compound is lipophilic and poorly soluble in water, prepare stock solutions in organic solvents such as methanol, ethanol, acetone, or DMSO, and use containers compatible with the chosen solvent. Handle the material inside a fume hood or a suitably ventilated area, wearing gloves, a laboratory coat, and eye protection, and avoid inhaling dust during weighing. Label all prepared working solutions clearly with the solvent and preparation date, and dispose of residues and contaminated consumables in accordance with the laboratory's chemical waste procedures.

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