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TCI

CAS 13292-46-1

Rifampicin TCI R0079

Rifampicin TCI R0079

Chemical Identity

CAS No.
13292-46-1
PubChem
CID 135876149·SID 87560354
Formula
C43H58N4O12
Molecular weight
822.9 g/mol
Purity
>98.0%(T)
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-o
SMILES
C[C@H]1/C=C/C=C(/C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C)\C
InChIKey
JQXXHWHPUNPDRT-SBMPKVQQSA-N
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Rifampicin is a widely used antibiotic compound in biochemical and microbiological research. As a member of the rifamycin family, it plays a crucial role in laboratory settings by inhibiting the synthesis of nucleic acids, particularly RNA, in bacterial cells. This mechanism makes it an essential tool for studying microbial behavior and antibiotic resistance. Its broad application spans from basic research to advanced drug development, making it a versatile reagent in life science laboratories.

Rifampicin is favored for its chemical stability and solubility in organic solvents such as ethyl acrylate or acetone. These properties ensure consistent performance in various experimental conditions. Additionally, its resistance to extreme environmental conditions simplifies storage and handling, reducing the risk of degradation. The high purity and reliability of Rifampicin make it a trusted choice for researchers requiring accurate and reproducible results.

In Indonesian laboratories, Rifampicin is commonly used in public health, pharmacology, and microbiology research. It is frequently found in health research laboratories, universities, and diagnostic facilities. Its role in testing bacterial sensitivity and understanding antibiotic resistance mechanisms is vital for advancing scientific knowledge and improving healthcare practices.

  • Bacterial Sensitivity Testing: Rifampicin is used to assess the susceptibility of bacterial strains to antibiotics, aiding in the development of effective treatment protocols.
  • Antibiotic Resistance Research: It helps scientists study how bacteria develop resistance to antibiotics, contributing to the understanding of drug efficacy and resistance mechanisms.
  • Drug Development: Rifampicin serves as a model compound in the formulation and testing of new antimicrobial agents.
  • Microbial Metabolism Studies: Its ability to inhibit RNA synthesis makes it useful in investigating bacterial metabolic pathways and gene expression.
  • Diagnostic Applications: It is employed in diagnostic assays to identify and characterize bacterial infections, supporting accurate clinical and research diagnoses.

From the TCI brochure

  • RNA synthesis inhibitor; used as control in RNA staining of E. coli

Brand TCI
CAS number 13292-46-1
Molecular formula —
Purity —
Category Life Science > Biochemicals and Reagents > Antibiotics
Pack sizes Available in various quantities as per standard laboratory requirements
Physical form Solid powder
Storage Store in a cool, dry place away from light and moisture

Data from the TCI brochure

Concentration in LB medium100 µg/mL (E. coli culture, 37°C, 4 hours)

Source: TCI brochure LL093 (2025-09-18)

Rifampicin should be stored in a cool, dry environment, away from direct light and moisture to maintain its chemical stability. It is recommended to use airtight containers to prevent contamination and degradation. Due to its solubility in organic solvents, it should be handled with care to avoid exposure to incompatible substances. In laboratory settings, proper personal protective equipment (PPE) such as gloves and safety goggles should be worn during handling. Regular monitoring of storage conditions ensures the integrity of the compound remains intact for reliable experimental results.

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