3-Chloro-2,2,3,3-tetrafluoropropionic Acid TCI C2356

Chemical Identity

CAS No.: 661-82-5
PubChem: CID 2782491·SID 87561108
Formula: C3HClF4O2
Molecular weight: 180.48 g/mol
Purity: >98.0%(T)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 3-chloro-2,2,3,3-tetrafluoropropanoic acid
SMILES: C(=O)(C(C(F)(F)Cl)(F)F)O
InChIKey: XJRMCFMZGRJXEZ-UHFFFAOYSA-N
MDL: MDL00153099

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3-Chloro-2,2,3,3-tetrafluoropropionic Acid (TCI C2356) is a short-chain fluorinated carboxylic acid. Its α and β carbon atoms carry four fluorine atoms, and the end of the chain carries a single chlorine atom. In the laboratory it is used as a fluorinated building block to introduce a chlorotetrafluoroethyl fragment into target molecules. The carboxylic acid group can be converted into esters, amides, acyl halides, or salts. This makes the compound a practical starting point for researchers in fluorine chemistry, materials chemistry, and organic synthesis.

Fluorine is highly electronegative, so the fluorine atoms pull electron density strongly away from the carboxyl group. As a result, the compound is much more acidic than ordinary propionic acid, and its derivatives react differently. Fluorinated fragments are known to improve chemical and thermal stability, change lipophilicity, and affect the surface properties of molecules. The chlorine atom at the end of the chain allows further transformations that are not possible with purely perfluorinated analogues. This combination of a reactive acid group, a fluorinated backbone, and a terminal chlorine is why researchers working on materials and specialty chemicals find this compound useful.

In Indonesia, this material is relevant to university research groups working in fluorine chemistry, organic synthesis laboratories exploring new fluorinated intermediates, and materials science teams studying surface-active or thermally stable compounds. Postgraduate researchers can use it to prepare derivatives for structure–property studies, and industrial R&D laboratories can use it when screening specialty chemical candidates. Because it is supplied under the TCI brand, laboratories can work from consistent, well-documented reagent quality across repeated experiments and longer research projects.

TCI brochures (PDF)

Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 51

Related TCI products

Synthesis of fluorinated esters and amides, where the carboxylic acid group reacts readily to attach the chlorotetrafluoroethyl fragment to alcohols or amines in target molecules.
Preparation of acyl halide intermediates, which turn the acid into a more reactive species for coupling reactions in multistep organic synthesis routes that need fluorinated segments.
Materials chemistry research, because fluorinated fragments can improve chemical and thermal stability and change surface properties, which matters when designing specialty polymers or coatings.
Structure–property studies in fluorine chemistry, where the strong electron-withdrawing effect of the fluorine atoms makes the compound useful for comparing acidity and reactivity with non-fluorinated analogues.
Exploring further chain-end transformations, since the terminal chlorine atom offers a reactive site that purely perfluorinated building blocks lack, which widens the range of possible synthetic routes.

Brand	TCI (product code C2356)
CAS number	661-82-5
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes	as listed in the available product variants
Physical form	refer to the TCI product documentation and Certificate of Analysis
Storage	keep tightly closed in a cool, dry, well-ventilated place, following the TCI Safety Data Sheet

Store this compound in its original, tightly sealed container in a cool, dry, well-ventilated area, away from moisture, bases, and incompatible materials. Use containers made of chemically resistant material and keep labels intact and legible. Because this is a strongly acidic fluorinated carboxylic acid, handle it inside a fume hood and wear chemical-resistant gloves, safety goggles, and a laboratory coat. Do not inhale vapours, and avoid contact with skin and eyes. Read the TCI Safety Data Sheet before use, and dispose of waste as halogenated chemical waste in line with local regulations.

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