Methyl Pentafluoropropionate TCI P1352

Chemical Identity

CAS No.: 378-75-6
PubChem: CID 9783·SID 87575438
Formula: C4H3F5O2
Molecular weight: 178.06 g/mol
Purity: >98.0%(GC)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: methyl 2,2,3,3,3-pentafluoropropanoate
SMILES: COC(=O)C(C(F)(F)F)(F)F
InChIKey: JMKJCPUVEMZGEC-UHFFFAOYSA-N

Rp 1.060.500,00

~~Rp 757.050,00~~ Rp 1.060.500,00

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Methyl Pentafluoropropionate from TCI is the methyl ester of pentafluoropropionic acid. Its molecule carries a pentafluoroethyl group (C2F5) attached directly to the ester carbonyl. This makes it an important fluorinated building block in organofluorine chemistry. In the laboratory, its main role is as a source of the pentafluoroethyl group for building target molecules. Adding perfluoroalkyl groups is now common in pharmaceutical, agrochemical, and materials research, because fluorine atoms can significantly change a molecule's physical and biological properties. Chemists use this compound to add that fluorinated group in a controlled, predictable way.

Chemists choose this compound because the pentafluoroethyl group is strongly electron-withdrawing. As a result, its carbonyl carbon is much more electrophilic than that of an ordinary aliphatic ester, so it reacts readily with nucleophiles such as amines, enolates, and organometallic reagents. This reactivity makes it easy to prepare amides, β-diketones, and ketones that carry a C2F5 group. These intermediates can then be converted into a wide range of fluorinated heterocycles. Because it is a small, volatile methyl ester, any leftover reagent is also easy to remove once the reaction is complete, which simplifies work-up and purification.

In Indonesia, this material is relevant to medicinal chemistry laboratories, agrochemical synthesis groups, and university research teams working in organofluorine chemistry. Researchers who are developing new active compounds can use it to study how a pentafluoroethyl group affects a molecule's properties. Synthesis laboratories also use it to prepare fluorinated intermediates and heterocyclic scaffolds for further work. Because it comes from a recognised reagent brand, it gives academic and industrial laboratories a dependable starting material for both exploratory and routine fluorination work.

Related TCI products

Introducing a pentafluoroethyl group: The ester works as a direct source of the C2F5 group, so chemists can add this perfluoroalkyl group to target molecules during multistep synthesis.
Fluorinated amide synthesis: Its highly electrophilic carbonyl carbon reacts readily with amines, giving an efficient route to amides that carry a pentafluoroethyl group.
Preparing fluorinated β-diketones: Reacting it with enolates gives β-diketones bearing a C2F5 group, which are useful intermediates for further synthesis and for building ligands.
Pentafluoroethyl ketone synthesis: Organometallic reagents add to its activated ester carbonyl, so chemists can prepare ketones carrying the electron-withdrawing pentafluoroethyl group.
Building fluorinated heterocycles: The C2F5-bearing amides, diketones, and ketones made from this ester can be converted into many fluorinated heterocycles for pharmaceutical and agrochemical research.

Brand	TCI (product code P1352)
CAS number	378-75-6
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes	as listed on the product page for this item
Physical form	small, volatile methyl ester
Storage	keep in a tightly closed container in a cool, well-ventilated place, following the manufacturer's label and SDS

Store Methyl Pentafluoropropionate in its original, tightly sealed container in a cool, dry, well-ventilated area, away from heat sources, ignition sources, and incompatible materials such as strong bases and strong nucleophiles. Because the compound is volatile, close containers promptly after use to limit evaporation and vapour release. Handle it inside a fume hood and wear suitable personal protective equipment, including chemical-resistant gloves, safety goggles, and a laboratory coat. Avoid breathing vapours and avoid contact with skin and eyes. Always read and follow the manufacturer's Safety Data Sheet for detailed hazard, first-aid, and disposal information, and dispose of fluorinated waste according to local regulations.

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