N-(2'-Cyanobiphenyl-4-ylmethyl)-L-valine Methyl Ester Hydrochloride TCI C2475

Chemical Identity

CAS No.: 482577-59-3
PubChem: CID 16744793·SID 160871372
Formula: C20H22N2O2.HCl
Molecular weight: 358.87 g/mol
Purity: >98.0%(HPLC)(T)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: methyl (2S)-2-[[4-(2-cyanophenyl)phenyl]methylamino]-3-methylbutanoate;hydrochloride
SMILES: CC(C)C(C(=O)OC)NCC1=CC=C(C=C1)C2=CC=CC=C2C#N.Cl
InChIKey: AZQXUWUZQLZNIM-FYZYNONXSA-N
MDL: MDL08460094

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N-(2'-Cyanobiphenyl-4-ylmethyl)-L-valine Methyl Ester Hydrochloride (TCI C2475) is a derivative of the amino acid L-valine in its methyl ester form. Its amino group is alkylated with a 2'-cyanobiphenyl-4-ylmethyl framework, and the compound is supplied as the hydrochloride salt. This structure is known as an intermediate in synthetic routes to valsartan, an antihypertensive drug in the angiotensin II receptor blocker class. Laboratories use it for drug synthesis research, peptide chemistry, and the development of pharmaceutical analytical methods.

The compound combines the chiral centre of L-valine with a biphenyl framework that carries a nitrile group. In the known synthetic route, the secondary amine is acylated with a valeryl group, the nitrile is then converted into a tetrazole ring, and the ester is finally hydrolysed. Because it is a hydrochloride salt, the material is a solid that is easier to handle and weigh than its free base. Its preserved chirality also matters when chemists study the enantiomeric purity of the final product.

The Indonesian pharmaceutical industry produces a wide range of generic medicines, including drugs in the sartan class. R&D and QC laboratories in Indonesia therefore need well-defined intermediates and reference compounds to study synthetic routes, follow how impurities form, and develop analytical methods. University research groups working in medicinal chemistry and peptide chemistry can also use this TCI compound as a starting material or a model compound for teaching and research.

TCI brochures (PDF)

Amino Acids and Peptide Synthesis Reagents 2025-08-14 · p. 23

Related TCI products

Sartan synthesis route studies: this compound is a known intermediate in valsartan synthesis, so chemists can use it to reproduce, evaluate, or optimise the acylation, tetrazole formation, and ester hydrolysis steps.
Peptide and amino acid chemistry: as an N-alkylated L-valine methyl ester, it is a useful example for studying how protected and modified amino acid derivatives behave in coupling and acylation reactions.
Pharmaceutical analytical method development: QC and R&D laboratories can use it as a reference compound when they develop chromatographic methods to separate and identify intermediates in sartan production.
Enantiomeric purity studies: the preserved chiral centre from L-valine lets researchers examine whether stereochemistry is retained through later synthetic steps and assess the enantiomeric purity of the final product.
Medicinal chemistry teaching and research: the molecule combines a chiral amino acid, a biphenyl framework, and a nitrile group, so it works well as a model compound for showing functional group transformations in drug synthesis.

Brand	TCI (product code C2475)
CAS number	482577-59-3
Molecular formula	—
Purity	—
Category	Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes	please refer to the available pack size options on the product listing
Physical form	solid (hydrochloride salt)
Storage	follow the conditions stated on the TCI label and Safety Data Sheet

Keep this compound in its original, tightly closed container in a cool, dry, well-ventilated place, away from moisture and direct sunlight. Follow the storage temperature and conditions given on the TCI label and in the Safety Data Sheet (SDS). Always reseal the container after use so the solid does not absorb atmospheric moisture. Handle the material only in a laboratory with suitable ventilation, preferably a fume hood, and wear standard personal protective equipment: a lab coat, chemical-resistant gloves, and safety glasses. Do not inhale the dust and avoid contact with skin and eyes. Read the SDS before first use, and dispose of waste according to institutional procedures and applicable regulations.

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